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首页> 外文期刊>Annual review of cell and developmental biology >Stellate Cells in Tissue Repair, Inflammation, and Cancer
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Stellate Cells in Tissue Repair, Inflammation, and Cancer

机译：组织修复，炎症和癌症中的星状细胞

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摘要

Stellate cells are resident lipid-storing cells of the pancreas and liver that transdifferentiate to a myofibroblastic state in the context of tissue injury. Beyond having roles in tissue homeostasis, stellate cells are increasingly implicated in pathological fibrogenic and inflammatory programs that contribute to tissue fibrosis and that constitute a growth-permissive tumor microenvironment. Although the capacity of stellate cells for extracellular matrix production and remodeling has long been appreciated, recent research efforts have demonstrated diverse roles for stellate cells in regulation of epithelial cell fate, immune modulation, and tissue health. Our present understanding of stellate cell biology in health and disease is discussed here, as are emerging means to target these multifaceted cells for therapeutic benefit.
机译：星状细胞是胰腺和肝脏的驻留脂质储存细胞，其在组织损伤的背景下转移到肌纤维囊肿状态。 除了在组织稳态中具有作用的作用，星状细胞越来越涉及有助于组织纤维化的病理纤维化和炎性程序，并且构成生长允许肿瘤微环境。 尽管对细胞外基质产生和重塑的星状细胞的能力长期以来，但是最近的研究努力在上皮细胞命运，免疫调制和组织健康调节中表现出具有星状细胞的多样性作用。 我们本发明讨论了对健康和疾病中星状细胞生物学的了解，因为靶向这些多方面细胞进行治疗益处的新兴手段。

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