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首页> 外文期刊>Annual review of cell and developmental biology >Architecture and Dynamics of the Neuronal Secretory Network
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Architecture and Dynamics of the Neuronal Secretory Network

机译：神经元分泌网络的建筑和动态

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摘要

Regulated synthesis and movement of proteins between cellular organelles are central to diverse forms of biological adaptation and plasticity.In neurons, the repertoire of channel, receptor, and adhesion proteins displayed on the cell surface directly impacts cellular development, morphology, excitability, and synapse function.The immensity of the neuronal surface membrane and its division into distinct functional domains present a challenging landscape over which proteins must navigate to reach their appropriate functional domains.This problem becomes more complex considering that neuronal protein synthesis is continuously refined in space and time by neural activity.Here we review our current understanding of how integral membrane and secreted proteins important for neuronal function travel from their sites of synthesis to their functional destinations.We discuss how unique adaptations to the function and distribution of neuronal secretory organelles may facilitate local protein trafficking at remote sites in neuronal dendrites to support diverse forms of synaptic plasticity.
机译：细胞细胞器之间的蛋白质的受调节合成和运动是不同形式的生物适应和塑性的核心。在细胞表面上显示的通道，受体和粘附蛋白的神经元，直接影响细胞发育，形态，兴奋性和突触功能。神经元表面膜的沉浸性和其分裂成明显的功能域具有挑战性的景观，蛋白质必须导航以达到适当的功能域。考虑到神经元蛋白质合成在空间和神经网络中连续地精制时变得更复杂活动。我们目前的审查了对神经元函数的整体膜和分泌蛋白质从其统一性目的地出发的重要膜和分泌蛋白质的理解。我们讨论了对神经元分泌细胞器的功能和分布的独特适应可以促进局部蛋白质TRAF在神经元德内德的偏远地点剥夺，以支持各种形式的突触塑性。

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