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首页> 外文期刊>Annual review of chemical and biomolecular engineering >Advances in Multicompartment Mesoporous Silica Micro/Nanoparticles for Theranostic Applications
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Advances in Multicompartment Mesoporous Silica Micro/Nanoparticles for Theranostic Applications

机译：用于治疗型应用的多量介孔二氧化硅微/纳米粒子的进展

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Mesoporous silica nanoparticles (MSNs) are promising functional nanomaterials for a variety of biomedical applications, such as bioimaging, drug/gene delivery, and cancer therapy. This is due to their low density, low toxicity, high biocompatibility, large specific surface areas, and excellent thermal and mechanical stability. The past decade has seen rapid advances in the development of MSNs with multiple compartments. These include hierarchical porous structures and core-shell, yolk-shell, and Janus structured particles for efficient diagnosis and therapeutic applications. We review advances in this area, covering the categories of multicompartment MSNs and their synthesis methods, with an emphasis on hierarchical structures and the incorporation of multiple functions. We classify multicompartment mesoporous silica micro/nanostructures, ranging from core-shell and yolk-shell structures to Janus and raspberry-like nanoparticles, and discuss their synthesis methods. We review applications of these multicompartment MSNs, including bioimaging, targeted drug/gene delivery, chemotherapy, phototherapy, and in vitro diagnostics. We also highlight the latest trends and new opportunities.
机译：中孔二氧化硅纳米颗粒（MSN）是对各种生物医学应用的功能性纳米材料，例如生物体，药物/基因递送和癌症治疗。这是由于它们的低密度，低毒性，高生物相容性，大的比表面积，以及出色的热和机械稳定性。过去十年已经看到，在具有多个隔间的MSNS的发展中已经快速进展。这些包括分层多孔结构和核心 - 壳，蛋白壳和Janus结构化颗粒，用于有效诊断和治疗应用。我们审查了该领域的进步，涵盖了多组分MSN和其合成方法的类别，重点是分层结构和多种功能的融合。我们分类多组介孔二氧化硅微/纳米结构，从核 - 壳和蛋白质壳结构到Janus和覆盆子样纳米粒子，并讨论它们的合成方法。我们审查这些多组分MSN的应用，包括生物体，靶向药/基因递送，化疗，光疗和体外诊断。我们还突出了最新的趋势和新的机会。

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