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首页> 外文期刊>Annals of epidemiology >Risk factors for pregnancy-associated breast cancer: A report from the Nigerian Breast Cancer Study
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Risk factors for pregnancy-associated breast cancer: A report from the Nigerian Breast Cancer Study

机译：怀孕相关乳腺癌的危险因素：尼日利亚乳腺癌研究的报告

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Purpose: Little is known about risk factors for pregnancy-associated breast cancer (PABC), diagnosed during pregnancy or postpartum. Methods: We enrolled 1715 premenopausal women from the Nigerian Breast Cancer Study from 1998 to2011. Based on recency of last pregnancy from diagnosis, breast cancer cases were categorized as (1) PABC diagnosed 2 years or longer postpartum, (2) PABC diagnosed 3 to 5years postpartum, or (3) non-PABC diagnosed more than 5 years postpartum. Controls were matched to cases on recency of last pregnancy. Multiple logistic regressions were performed comparing cases and controls within eachgroup. Results: Of the 718 cases, 152 (21.2%) had PABC 2 or more years postpartum, and 145 (20.2%) 3 to 5years postpartum. Although not statistically significant, women with higher parity tend to have an elevated risk of PABC but reduced risk of non-PABC (p for heterogeneity=0.097). Family history of breast cancer might be a strong predictor particularly for PABC 2 or more years postpartum (odds ratio,3.28; 95% confidence interval, 1.05-10.3). Compared with non-PABC cases, PABC 2or more years postpartum cases were more likely to carry BRCA1/2 mutations (P= .03). Conclusions: Parity may have different roles in the development of PABC versus other premenopausal breast cancer in Nigerian women. Prospective mothers with multiple births and a family history of breast cancer may have an elevated risk of breast cancer during their immediate postpartum period.
机译：目的：关于妊娠期相关乳腺癌（PABC）的危险因素，令人难以诊断，妊娠期或产后诊断。方法：从1998年到2011年，我们从尼日利亚乳腺癌学习中注册了1715名前列女性。基于上次妊娠的新近度从诊断中，乳腺癌病例分类为（1）PABC诊断为2年或更长的产后，（2）PABC诊断为3至5年产后，或（3）非PABC诊断出5年以上的产后。对照对上次怀孕的案件进行了匹配。执行多元逻辑回归比较每个群体内的情况和控件。结果：718例，152例（21.2％）PABC 2或更多年产后，145（20.2％）3至5年产后。虽然没有统计学意义，但具有较高奇偶阶层的女性倾向于具有pABC的风险升高，但是非PABC的风险降低（用于异质性= 0.097）。乳腺癌的家族史可能是一个强有力的预测因子，特别是PABC 2或更多年产后（赔率比，3.28; 95％置信区间，1.05-10.3）。与非PABC案例相比，PABC 200R产后患者的患者更容易携带BRCA1 / 2突变（P = .03）。结论：平价可能对尼日利亚女性的PABC与其他前肢乳腺癌的发展产生不同的作用。患有多个出生和乳腺癌家族史的前瞻性母亲可能在后期后期乳腺癌的风险升高。

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  • 来源
    《Annals of epidemiology》 |2013年第9期|共7页
  • 作者

    HouN.; OgundiranT.; OjengbedeO.; Morhason-BelloI.; ZhengY.; FackenthalJ.; AdebamowoC.; AnetorI.; AkinleyeS.; OlopadeO.I.; HuoD.;

  • 作者单位

    Department of Health Studies University of Chicago Chicago IL United States;

    Department of Surgery College of Medicine University of Ibadan Ibadan Nigeria;

    Center for Population and Reproductive Health College of Medicine University of Ibadan Ibadan;

    Center for Population and Reproductive Health College of Medicine University of Ibadan Ibadan;

    Center for Clinical Cancer Genetics and oGlobal Health Department Medicine University of Chicago;

    Center for Clinical Cancer Genetics and oGlobal Health Department Medicine University of Chicago;

    Department of Epidemiology and Preventive Medicine University of Maryland Baltimore MD United;

    Healthy Life for All Foundation Ibadan Nigeria;

    Healthy Life for All Foundation Ibadan Nigeria;

    Center for Clinical Cancer Genetics and oGlobal Health Department Medicine University of Chicago;

    Department of Health Studies University of Chicago Chicago IL United States;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 流行病学与防疫;
  • 关键词

    Case-control study; Nigerian; Pregnancy-associated breast cancer; Risk factors;

    机译：案例对照研究;尼日利亚;妊娠相关的乳腺癌;危险因素;

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