...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Annals of epidemiology >A high anticholinergic burden is associated with a history of falls in the previous year in middle-aged women: findings from the Aberdeen Prospective Osteoporosis Screening Study
【24h】

A high anticholinergic burden is associated with a history of falls in the previous year in middle-aged women: findings from the Aberdeen Prospective Osteoporosis Screening Study

机译：高抗胆碱能负担与上一年中的秋季历史有关：来自阿伯丁骨质疏松症筛查研究的发现

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PurposeTo examine the cross-sectional association between anticholinergic medication burden (ACB) and a history of falls, bone mineral density, and low trauma fractures in middle-aged women aged under 65?years from the Aberdeen Prospective Osteoporosis Screening Study. MethodsACB (0?=?none, 1?= possible, ≥2?=?definite) was calculated from medication use for 3883 Caucasian women [mean age (SD)?=?54.3 (2.3) years] attending the second Aberdeen Prospective Osteoporosis Screening Study visit (1997–2000). Outcomes were examined using logistic regression. Model adjustments were selected a priori based on expert opinion. ResultsOf 3883 participants, 3293 scored ACB?=?0, 328 scored ACB?=?1, and 262 scored ACB ≥2. High ACB burden (≥2) was associated with increased odds (ACB?= 0 reference) for falls (fully adjusted odds ratio [95% confidence intervals]?=?1.81 [1.25–2.62];P?= 0.002) and having low bone mineral density (lowest quintile-20%) at Ward's triangle (3.22 [1.30–7.99];P?= 0.01). A history of falls over the year prior to the study visit in participants with ACB score ≥2 was 32 per 100. For ACB categories 1 and 0, a history of falls per 100 was 21 and 22, respectively. ConclusionsThe risk of falling associated with ACB observed in older age may also extend to middle-aged women.
机译：Purposeto检查抗胆碱能药物负担（ACB）与跌倒，骨矿物密度和65岁以下的中年女性患者历史之间的横截面关联，从Aberdeen骨质疏松症筛查研究中的中年妇女中的中年女性。方法（0？=？没有，1？=可能，≥2？=？确定）从药物用途中计算3883个白种人女性[意思年龄（SD）吗？=？54.3（2.3）岁]参加第二次阿伯丁骨质疏松症筛选研究访问（1997-2000）。使用Logistic回归检查结果。根据专家意见选择了模型调整。结果3883名参与者，3293次得分ACB？=？0,328得分ACB？=？1，262得分ACB≥2。高ACB负担（≥2）与下降的赔率增加（ACB？= 0参考）相关（完全调整的差距[95％置信区间]？=？1.81 [1.25-2.62]; p？= 0.002）并低病房三角形（3.22 [1.3.2-7.99]; P？= 0.01）。在研究ACB得分≥2的参与者的参与者前一年中的一年中的历史为每100次。对于ACB类别1和0，每100次跌幅分别为21和22。结论较老年人观察到的ACB与ACB相关的风险也可能延伸到中年妇女。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号