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首页> 外文期刊>Acta physiologica >The importance of being rhythmic: Living in harmony with your body clocks
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The importance of being rhythmic: Living in harmony with your body clocks

机译:具有节奏的重要性:与您的身体时钟和谐一起生活

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摘要

Abstract Circadian rhythms have developed in all light‐sensitive organisms, including humans, as a fundamental anticipatory mechanism that enables proactive adaptation to environmental changes. The circadian system is organized in a highly hierarchical manner, with clocks operative in most cells of the body ensuring the temporal coordination of physiological processes. Circadian misalignment, stemming from modern life style, draws increasing attention due to its tight association with the development of metabolic, cardiovascular, inflammatory and mental diseases as well as cancer. This review highlights recent findings emphasizing the role of the circadian system in the temporal orchestration of physiology, with a particular focus on implications of circadian misalignment in human pathologies.
机译:摘要昼夜节律在所有光敏的生物体中都开发,包括人类,作为一种基本的预期机制,使得能够积极适应环境变化。 昼夜节律系统以高度分层的方式组织,在体内的大多数细胞中均以确保生理过程的时间协调。 来自现代生活方式的昼夜丧失,由于其与新陈代谢,心血管,炎症和精神疾病以及癌症的关系紧张,因此引起了越来越多的关注。 本综述突出了最近调查结果强调昼夜节约系统在生理学中的作用,特别侧重于昼夜对人类病理中的影响。

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