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首页> 外文期刊>ANZ journal of surgery >Impact of atrial fibrillation on long‐term survival following oesophagectomy: a 21‐year observational study
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Impact of atrial fibrillation on long‐term survival following oesophagectomy: a 21‐year observational study

机译:心房颤动对卵泡切除术后长期存活的影响:21年的观察研究

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Background Post‐operative atrial fibrillation ( AF ) is a common complication of oesophagectomy and thought to signal a complicated post‐operative course. AF is associated with prolonged admissions, increased healthcare costs and inpatient mortality. However, the impact of post‐operative AF on long‐term outcomes remains uncertain. Methods Patients undergoing open Ivor‐Lewis oesophagectomy from 1994 to 2014 at Palmerston North Hospital, New Zealand, were retrospectively evaluated. Demographic, perioperative and tumour variables were collected. Regression models were used to identify independent predictors of AF and assess post‐discharge survival following oesophagectomy. Results In total, 89 patients were included. New‐onset AF developed post‐operatively in 27 patients (30%). Median follow‐up was 6.3?years. Logistic regression identified volume of intravenous fluid in the first 24?h post‐operatively as a predictor of AF . Post‐discharge survival was predicted by AF occurrence (hazard ratio ( HR ): 2.99, 95% confidence interval ( CI ): 1.37–6.53, P ?=?0.006), preoperative chemoradiotherapy ( HR : 0.43, 95% CI : 0.20–0.91, P ?=?0.03), 1–4 positive lymph nodes ( HR : 2.29, 95% CI : 1.06–4.96, P ?=?0.04), ≥5 positive nodes ( HR : 2.95, 95% CI : 1.25–6.94, P ?=?0.01) and year of operation from 2008 to 2014 ( HR : 0.30, 95% CI : 0.12–0.75, P ?=?0.01). Conclusion Post‐operative AF was associated with poorer long‐term survival following oesophagectomy in this cohort. Further research should evaluate the influence of AF on cardiovascular and oncological outcomes following oesophagectomy.
机译:背景技术术后心房颤动(AF)是卵泡切除术的常见并发症,并思考发出复杂的术后课程。 AF与长期录取有关,增加医疗保健成本和住院死亡率。然而,操作术后AF对长期结果的影响仍然不确定。方法回顾性评估1994年至2014年在1994年至2014年接受开放的Ivor-Lewis Oesophiccoctomy的患者。收集人口统计学,围手术期和肿瘤变量。回归模型用于鉴定AF的独立预测因子,并在食道切除术后评估放电后存活。结果总计89名患者。新手AF在27名患者中可操作地开发(30%)。中位后续时间为6.3?多年。后24Ω·H的静​​脉内流体的体积可操作地作为AF的预测标识识别。出现后存活率被AF发生预测(危险比(HR):2.99,95%置信区间(CI):1.37-6.53,P?=?0.006),术前化学疗法(HR:0.43,95%CI:0.20- 0.91,p?= 0.03),1-4个阳性淋巴结(HR:2.29,95%CI:1.06-4.96,P?= 0.04),≥5个阳性节点(HR:2.95,95%CI:1.25- 6.94,p?= 0.01)和2008年至2014年的运营年份(HR:0.30,95%CI:0.12-0.75,P?= 0.01)。结论在这种队列中卵泡切除术后的术后AF与较差的长期存活相关。进一步的研究应评估OFOP结发术后AF对心血管和肿瘤性结果的影响。

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