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首页> 外文期刊>ANZ journal of surgery >Pathological prognostic factors of recurrence in early stage lung adenocarcinoma
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Pathological prognostic factors of recurrence in early stage lung adenocarcinoma

机译：早期肺腺癌复发的病理预后因素

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摘要

Background Histological heterogeneity is thought to be important for prognosis of lung adenocarcinoma. We investigated to determine pathological features with prognostic value for recurrence of early stage lung cancer. Methods A total of 368 patients who underwent curative surgical resection for early stage lung adenocarcinoma between 2009 and 2012 were enrolled. Pathologic characteristics including the presence of visceral pleural invasion, micropapillary patterns, aerogenous spread, lymphovascular invasion, perineural invasion and necrosis were examined. The correlations between pathological factors and clinical outcomes were analysed to determine prognostic significance. Results Mean follow‐up was 43.0?months (±14.56, ranging from 0.0 to 73.9?months). Three‐year overall survival was 95.2% and disease‐free survival was 89.8%. The recurrence rate was 9.0% (33 patients) and the mortality rate was 6.0% (22 patients). The presence of a micropapillary pattern ( P ??0.002), lymphatic invasion ( P ??0.000), aerogenous spread ( P ??0.000), vascular invasion ( P ?=?0.036) and necrosis ( P ??0.000) were negative prognostic factors of recurrence in univariate analysis. In multivariate analysis, only aerogenous spread had prognostic value ( P ?=?0.020). The recurrence hazard ratio for the presence of aerogenous spread was 3.2 (95% confidence interval 1.20–8.47). Conclusion The presence of aerogenous spread was an independent pathological risk factor of recurrence in stage I lung adenocarcinoma. Micropapillary pattern had prognostic importance for recurrence in univariate analysis, but not in multivariate analysis.
机译：背景技术组织学异质性被认为对肺腺癌预后是重要的。我们研究了确定具有预后价值的病理特征，用于早期肺癌复发。方法共有368例接受治疗手术切除治疗早期肺腺癌的368名患者。检查病理特征，包括内耳胸腔侵袭，微杂种图案，曝气蔓延，淋巴血管侵袭，危害侵袭和坏死的存在。分析了病理因子与临床结果之间的相关性以确定预后意义。结果平均随访时间为43.0？月（±14.56，范围为0.0至73.9？月）。为期三年的总生存率为95.2％，免疫存活率为89.8％。复发率为9.0％（33名患者），死亡率为6.0％（22名患者）。微毛细血管图案的存在（p≤≤0.002），淋巴侵入（p≤≤0.000），血管侵袭（p≤≤0.000），血管侵袭（p？= 0.036）和坏死（p Δ≤0.10）是单变量分析中复发的负预后因素。在多变量分析中，只有曝气扩散具有预后值（P？= 0.020）。曝气扩散的存在的复发危险比为3.2（95％置信区间1.20-8.47）。结论曝气扩散的存在是阶段I肺腺癌中复发的独立病理危险因素。微杂种图案对单变量分析的复发性具有预后重要性，但不具有多变量分析。

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  • 来源
    《ANZ journal of surgery》 |2018年第4期|共1页
  • 作者

    Yi Eunjue; Bae Mi‐Kyeong; Cho Sukki; Chung Jin‐Haeng; Jheon Sanghoon; Kim Kwhanmien;

  • 作者单位

    Department of Thoracic and Cardiovascular SurgeryKorea University Anam HospitalSeoul Republic of;

    Department of Thoracic SurgeryNational Health Insurance Service Ilsan HospitalGyeonggi Republic of;

    Department of Thoracic and Cardiovascular SurgerySeoul National University Bundang HospitalGyeonggi;

    Department of PathologySeoul National University Bundang HospitalGyeonggi Republic of Korea;

    Department of Thoracic and Cardiovascular SurgerySeoul National University Bundang HospitalGyeonggi;

    Department of Thoracic and Cardiovascular SurgerySeoul National University Bundang HospitalGyeonggi;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 外科学;
  • 关键词

    diagnosis; lung cancer; outcomes; pathology;

    机译：诊断;肺癌;结果;病理学;

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