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首页> 外文期刊>American Journal of Sports Medicine >Effect of Suture Absorbability on Rotator Cuff Healing in a Rabbit Rotator Cuff Repair Model
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Effect of Suture Absorbability on Rotator Cuff Healing in a Rabbit Rotator Cuff Repair Model

机译：缝合吸收性对兔子箍箍修复模型旋转箍愈合的影响

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摘要

Background: Various suture materials can be clinically used for rotator cuff repair (RCR). RCR with high-strength nonabsorbable sutures may not be ideal, because it may cause stress shielding, which may hinder enthesis regeneration and maturation in the tendon-bone interface. RCR with strength-decreasing sutures (ie, absorbable sutures) may be a better choice. However, the effects of suture absorbability on enthesis regeneration and maturation have not been investigated. Hypothesis: The use of absorbable sutures in RCR would produce a better tendon-bone connection structure, which provides histological and biomechanical advantages over the use of nonabsorbable sutures. Study Design: Controlled laboratory study. Methods: A supraspinatus tear was created on the right shoulder in 108 of 120 skeletally mature male rabbits. The animals were randomly divided into 3 groups, with 36 rabbits in each group, to undergo RCR individually with total absorbable, partial absorbable, and nonabsorbable sutures (TAS, PAS, and NAS). Twelve animals in each group were sacrificed at 4, 8, and 12 weeks after surgery, with 6 operated shoulders used for histological evaluation to detect enthesis regeneration and maturation and the other 6 for biomechanical testing. The remaining 12 animals without supraspinatus tear were used as control. Results: At 12 weeks, in the tendon-bone interface, enthesis regeneration was detected in the TAS group but not in the NAS group. A mature enthesis appeared in the TAS group but not in the NAS group. In the PAS group, enthesis regeneration was also observed; however, the fibrocartilage was not abundant and the enthesis maturity not good as compared with the TAS group. Biomechanical testing showed that the rotator cuff–greater tuberosity connection structure in the TAS and PAS groups had greater values of ultimate load to failure, stiffness, and stress than the NAS group at all time points. Conclusion: In RCR in an acute rabbit rotator cuff tear model, the use of sutures with absorbability lead to enthesis regeneration, increased maturity of rotator cuff insertion, and enhanced rotator cuff–greater tuberosity connection. Clinical Relevance: Compared with the use of NAS, the use of TAS or PAS might be a better choice for RCR.
机译：背景：各种缝合材料可以临床上用于旋转箍修复（RCR）。 RCR具有高强度非可吸收的缝合线可能不是理想的，因为它可能导致应力屏蔽，这可能妨碍肌腱 - 骨界面中的休息再生和成熟。 RCR具有强度降低缝合线（即可吸收缝合线）可能是更好的选择。然而，缝合性吸收性对诊断再生和成熟的影响尚未得到研究。假设：在RCR中使用可吸收缝合线将产生更好的肌腱 - 骨连接结构，这提供了通过使用非可吸收缝合线的组织学和生物力学优势。研究设计：受控实验室研究。方法：在120个骨骼成熟的雄性兔中的右肩上产生冈上肌酐。将动物随机分为3组，每组中具有36只兔子，用全部可吸收，部分可吸收和非可吸收的缝合线（TA，PAS和NAs）单独进行RCR。在手术后4,8和12周处处死12个动物的12个动物，其中6个操作的肩部用于组织学评估，以检测患有再生和成熟，另一个用于生物力学测试。剩余的12只没有冈上肌肉撕裂的动物被用作对照。结果：12周，在肌腱骨界面中，在TAS组中检测到肠杆菌再生，但不在NAS组中。在TAS组中出现了成熟的诱人，但不在NAS组中。在PAS组中，还观察到诊断再生;然而，与TAS组相比，纤维纤维率并不丰富，并且肠道成熟不良。生物力学测试表明，TAS和PAS组中的转子袖带较大的结节连接结构具有更大的终极载荷值，与所有时间点的NAS组比NAS组更大。结论：在急性兔子肩袖撕裂模型中的RCR中，利用吸收性的缝合线引入诊断再生，旋转箍插入的成熟度增加，以及增强的旋转器袖口 - 较大的结节连接。临床相关性：与使用NAS相比，使用TAS或PAS可能是RCR的更好选择。

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  • 来源
    《American Journal of Sports Medicine》 |2018年第11期|共12页
  • 作者

    Wei Su; Wenxiao Qi; Xiaoxi Li; Song Zhao; Jia Jiang; Jinzhong Zhao;

  • 作者单位

    Department of Sports Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital;

    Department of Sports Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital;

    Department of Sports Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital;

    Department of Sports Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital;

    Department of Sports Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital;

    Department of Sports Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 运动医学;
  • 关键词

    rotator cuff repair; suture absorbability; enthesis regeneration;

    机译：转子袖带修复;缝合吸收性;禁止再生;

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