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Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile (2nd edition)

机译：抗病毒化学和化疗的目前的抗病毒药物事件（第2版）

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摘要

The concept of antiviral FactFiles dates from May 1994 with the publication in the (now discontinued) International AntiViral News of a table of mutations in HIV reverse transcriptase and protease associated with antiviral drug resistance, which was compiled by Raymond Schinazi and colleagues [1]. This was followed in May of the following year by the first Current Antiviral Agents FactFile [2,3]. This was also published in International AntiViral News in two parts: the first dealing with herpesviruses, hepatitis viruses and respiratory viruses, and the second dealing with HIV. The original versions were compiled by Drs Sian Goldthorpe, Derek Kinchington and Ms Lisa Lovelidge. The idea was conceived for essentially selfish reasons -my desire for a convenient aide memoire to the current antiviral agents to take to meetings or to keep to hand when writing on the subject of antiviral chemotherapy. Thus, the first edition aimed to 'provide a concise source of reference covering the principal antiviral agents'. It was intended that the list was to be restricted to those compounds that had at least potential for therapeutic use. It was always the intention, however, to include a few compounds that, although they were no longer used in the clinic, perhaps because of unacceptable toxicity, remained important in the history of the development of the field. The original FactFile documented a total of just 51 compounds.
机译：抗病毒事件的概念从1994年5月开始于（现已停产）的出版物，在艾滋病病毒逆转录酶和抗病毒性抗性相关的蛋白酶中的突变表中的出版物，由雷蒙斯施扎伊和同事编制了抗病毒耐药性的蛋白酶[1]。在次年五月的第一个目前的抗病毒药物事件[2,3]可能是遵循这一点。这也在两部分中发表在国际抗病毒新闻中：首次处理疱疹病毒，肝炎病毒和呼吸道病毒，以及与艾滋病毒的第二种处理。原始版本由Drs Sian Goldthorpe，Derek Kinchington和Lisa Lovelidge编制。这个想法是为了获得基本上自私的原因 - 利于方便的辅助寄存器对当前的抗病毒品代理人参加会议或在写入抗病毒化疗的主题时遵守。因此，第一版旨在'提供涵盖主要抗病毒药物的简洁源。目的是，该名单应限于至少治疗使用可能性的那些化合物。然而，它始终是包含几种化合物，尽管它们不再在诊所中使用，但可能因为不可接受的毒性，在该领域的发展历史中仍然很重要。原始事件造成的总共只有51个化合物。

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