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Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile (2nd edition)

机译：抗病毒化学和化学疗法当前的抗病毒剂FactFile（第二版）

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摘要

The concept of antiviral FactFiles dates from May 1994 with the publication in the (now discontinued) International AntiViral News of a table of mutations in HIV reverse transcriptase and protease associated with antiviral drug resistance, which was compiled by Raymond Schinazi and colleagues [1]. This was followed in May of the following year by the first Current Antiviral Agents FactFile [2,3]. This was also published in International AntiViral News in two parts: the first dealing with herpesviruses, hepatitis viruses and respiratory viruses, and the second dealing with HIV. The original versions were compiled by Drs Sian Goldthorpe, Derek Kinchington and Ms Lisa Lovelidge. The idea was conceived for essentially selfish reasons -my desire for a convenient aide memoire to the current antiviral agents to take to meetings or to keep to hand when writing on the subject of antiviral chemotherapy. Thus, the first edition aimed to 'provide a concise source of reference covering the principal antiviral agents'. It was intended that the list was to be restricted to those compounds that had at least potential for therapeutic use. It was always the intention, however, to include a few compounds that, although they were no longer used in the clinic, perhaps because of unacceptable toxicity, remained important in the history of the development of the field. The original FactFile documented a total of just 51 compounds.
机译：抗病毒FactFiles的概念可以追溯到1994年5月，在国际抗病毒新闻（现已停产）中发表了与抗病毒药物耐药性相关的HIV逆转录酶和蛋白酶突变表，该表由Raymond Schinazi及其同事编辑[1]。第二年5月发布了第一个Current Antiviral Agents FactFile [2,3]。这也发表在《国际抗病毒新闻》上，分为两个部分：第一部分涉及疱疹病毒，肝炎病毒和呼吸道病毒，第二部分涉及艾滋病毒。原始版本由Sian Goldthorpe博士，Derek Kinchington和Lisa Lovelidge女士编辑。这个想法的产生主要是出于自私的原因-我希望有一份方便的备忘录来回忆当前的抗病毒药物，以便在撰写抗病毒化学疗法主题时参加会议或与会。因此，第一版旨在“提供涵盖主要抗病毒药物的简明参考资料”。意图将该列表限于至少具有治疗用途潜力的那些化合物。然而，总的意图是包括一些化合物，尽管它们不再用于临床，可能是因为毒性不可接受，但在该领域的发展历史中仍然很重要。原始FactFile记录总共只有51种化合物。

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