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Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile (2nd edition): DNA viruses

机译:抗病毒化学和化疗的目前的抗病毒剂FACTFILE(第2版):DNA病毒

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摘要

Although most of the recent attempts to develop new antiviral agents have been focussed on RNA viruses (in particular, HIV and hepatitis C virus), a few new compounds are now awaiting their entry into the field of DNA viruses, particularly poxviruses, such as variola virus, because of the bioterrorist context, and herpesviruses, such as herpes simplex virus and cytomegalovirus, where the market scene has for many years been dominated by acyclovir, penciclovir and ganciclovir and their respective orally bioavailable prodrugs: valaciclovir, famciclovir and valganciclovir. Here, we review the current 'state of the art' with old compounds ready to rotate off and new compounds eagerly awaiting to appear on the continuously evolving scene of antiviral drug development.
机译:尽管最近开发新的抗病毒药物的大部分尝试都集中于RNA病毒(特别是艾滋病毒和丙型肝炎病毒),但是几种新化合物现在正在等待其进入DNA病毒,特别是痘病毒,例如Variola 由于生物恐怖主义的背景,并且疱疹病毒,如疱疹病毒和细胞瘤,其中市场现场多年来一直由Acyclovir,Penciclovir和Ganciclovir和他们各自口服生物可利用的前药中所导样:Valaciclovir,Famciclovir和Valganciclovir。 在这里,我们审查了当前的“艺术状态”,随时准备旋转的旧化合物,热切等待的新化合物出现在抗病毒药物开发的不断发展的场景上。

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