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首页> 外文期刊>Antiviral chemistry & chemotherapy >Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile (2nd edition): DNA viruses.
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Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile (2nd edition): DNA viruses.

机译：抗病毒化学和化学疗法当前的抗病毒药物概况（第二版）：DNA病毒。

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摘要

Although most of the recent attempts to develop new antiviral agents have been focussed on RNA viruses (in particular, HIV and hepatitis C virus), a few new compounds are now awaiting their entry into the field of DNA viruses, particularly poxviruses, such as variola virus, because of the bioterrorist context, and herpesviruses, such as herpes simplex virus and cytomegalovirus, where the market scene has for many years been dominated by acyclovir, penciclovir and ganciclovir and their respective orally bioavailable prodrugs: valaciclovir, famciclovir and valganciclovir. Here, we review the current 'state of the art' with old compounds ready to rotate off and new compounds eagerly awaiting to appear on the continuously evolving scene of antiviral drug development.
机译：尽管最近开发新抗病毒剂的大多数尝试都集中在RNA病毒（特别是HIV和丙型肝炎病毒）上，但一些新化合物正在等待进入DNA病毒领域，尤其是痘病毒（如天花）由于存在生物恐怖主义背景，病毒和疱疹病毒，例如单纯疱疹病毒和巨细胞病毒，多年来在市场上一直被阿昔洛韦，喷昔洛韦和更昔洛韦及其各自的口服生物可利用的前药：伐昔洛韦，泛昔洛韦和缬更昔洛韦所控制。在这里，我们回顾了当前的“技术水平”，其中有旧化合物准备好转售，而新化合物则迫切希望出现在抗病毒药物开发不断发展的场景中。

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