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首页> 外文期刊>Antiviral chemistry & chemotherapy >Important advances in the field of anti-dengue virus research.
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Important advances in the field of anti-dengue virus research.

机译：抗登革病毒研究领域的重要进展。

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摘要

There are currently no licensed antivirals available for the treatment of dengue virus (DENV), which causes significant morbidity and mortality throughout tropical areas of the world and is now encroaching on the southern United States. Recent improvements in existing animal models and cell culture systems have been very important in elucidating the mechanisms of DENV pathogenesis in humans, including the identification of potential viral and host proteins that might be targeted for the treatment of DENV infection. The AG129 mouse model is a major advance in the development of antiviral and vaccine candidates for clinical use. It allows for testing of potential therapeutics in a relevant system that exhibits some aspects of disease that are similar to those observed in humans. This review focuses on recent developments in the AG129 mouse model and discusses compounds that have been found to be active in available cell and animal model systems within the past year.
机译：目前没有可用于治疗登革热病毒（DENV）的许可抗病毒，这导致世界热带地区的显着发病和死亡率，现在正在侵犯美国南部。 最近的现有动物模型和细胞培养系统的改善对于阐明人类丹佛病发生机制非常重要，包括鉴定可能靶向治疗DENV感染的潜在病毒和宿主蛋白质。 AG129小鼠模型是抗病毒和疫苗候选者进行临床用途的主要进步。 它允许在表现出与人类观察到的那些类似的疾病的一些方面的相关系统中测试潜在的治疗方法。 本综述重点介绍AG129鼠标模型的最新进展，并讨论了过去一年内已发现在可用的细胞和动物模型系统中活跃的化合物。

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