The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host

Calvo-Pinilla Eva; Gubbins Simon; Mertens Peter; Ortego Javier; Castillo-Olivares Javier

首页> 外文期刊>Antiviral Research >The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host

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The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host

机译：基于修饰的痘苗病毒患者的重组疫苗的免疫原性表达非洲马病病毒VP2抗原的病毒取决于所表达的VP2蛋白递送给宿主的水平

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African horse sickness (AHS) is a lethal equine disease transmitted by Culicoides biting midges and caused by African horse sickness virus (AHSV). AHS is endemic to sub-Saharan Africa, but devastating outbreaks have been recorded periodically outside this region. The perceived risk of an AHS outbreak occurring in Europe has increased following the frequent epidemics caused in ruminants by bluetongue virus, closely related to AHSV.

机译：非洲马疾病（AHS）是由培养的致命马疾病咬住中介，由非洲马疾病病毒（AHSV）造成。艾哈斯为撒哈拉以南撒哈拉非洲流行，但在该地区之外定期记录了毁灭性的爆发。在BlueTongue病毒的反刍动物引起的频繁流行病中，欧洲发生的AHS爆发的感知风险增加了，与AHSV密切相关。

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来源
《Antiviral Research》 |2018年第2018期|共8页
作者
Calvo-Pinilla Eva; Gubbins Simon; Mertens Peter; Ortego Javier; Castillo-Olivares Javier;
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作者单位

Pirbright Inst Ash Rd Pirbright GU24 0NF Surrey England;

Pirbright Inst Ash Rd Pirbright GU24 0NF Surrey England;

Pirbright Inst Ash Rd Pirbright GU24 0NF Surrey England;

INIA CISA Madrid 28130 Spain;

Pirbright Inst Ash Rd Pirbright GU24 0NF Surrey England;

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原文格式 PDF
正文语种 eng
中图分类医学微生物学（病原细菌学、病原微生物学）;
关键词
African horse sickness; Vaccinia; MVA; VP2;

机译：非洲马疾病;痘苗;MVA;VP2;

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1. The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host [J] . Calvo-Pinilla Eva, Gubbins Simon, Mertens Peter, Antiviral Research . 2018,第期

机译：基于修饰的痘苗病毒患者的重组疫苗的免疫原性表达非洲马病病毒VP2抗原的病毒取决于所表达的VP2蛋白递送给宿主的水平
2. Vaccination of horses with a recombinant modified vaccinia Ankara virus (MVA) expressing African horse sickness (AHS) virus major capsid protein VP2 provides complete clinical protection against challenge. [J] . Alberca B., Bachanek-Bankowska K., Cabana M., Vaccine . 2014,第29期

机译：用表达非洲马瘟（AHS）病毒主要衣壳蛋白VP2的重组修饰牛痘安卡拉病毒（MVA）接种马匹，可提供针对挑战的完整临床保护。
3. Vaccination of mice with a modified Vaccinia Ankara (MVA) virus expressing the African horse sickness virus (AHSV) capsid protein VP2 induces virus neutralising antibodies that confer protection against AHSV upon passive immunisation [J] . Calvo-PinillaE., delaPozaF., GubbinsS., Virus Research: An International Journal of Molecular and Cellular Virology . 2014,第Null期

机译：用表达非洲马瘟病毒（AHSV）衣壳蛋白VP2的改良痘苗安卡拉（MVA）病毒对小鼠进行疫苗接种可诱导病毒中和抗体，从而在被动免疫后提供针对AHSV的保护
4. Protection induced by a recombinant replication-defective adenovirus vaccine expressing the P97 protein o￡ Mycoplasma byopneumoniae in challenged pigs: Comparison to Suvaxyn~R MH-one vaccine [C] . E R. Okamba, M. Arella, N. Music, Annual Meeting of the American Association of Swine Veterinarians . 2009

机译：通过重组复制缺陷的腺病毒疫苗诱导的保护，在挑战猪中表达P97蛋白O£opnoplasma opneumoniae：与Suvaxyn〜R MH-一疫苗相比
5. Effects of Modified Vaccinia Virus Ankara Expressing Mesothelin and the Poxvirus Immunoregulatory A35R gene in the Treatment of Murine Pancreatic Cancer [D] . Freistaedter, Andrew 2012

机译：表达间皮素和痘病毒免疫调节性A35R基因的痘苗病毒安卡拉对小鼠胰腺癌的治疗作用
6. The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host [O] . Eva Calvo-Pinilla, Simon Gubbins, Peter Mertens, -1

机译：基于表达非洲马瘟病毒VP2抗原的改良痘苗安卡拉（MVA）病毒的重组疫苗的免疫原性取决于递送至宿主的VP2蛋白表达水平
7. The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host [O] . Eva Calvo-Pinilla, Simon Gubbins, Peter Mertens, 2018

机译：基于修饰的痘苗病毒的重组疫苗的免疫原性表达非洲马疾病病毒VP2抗原的病毒取决于所表达的VP2蛋白递送给宿主的水平

The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host

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