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首页> 外文期刊>Antiviral Research >Aesculus hippocastanum L. seed extract shows virucidal and antiviral activities against respiratory syncytial virus (RSV) and reduces lung for updates inflammation in vivo
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Aesculus hippocastanum L. seed extract shows virucidal and antiviral activities against respiratory syncytial virus (RSV) and reduces lung for updates inflammation in vivo

机译：射击树木河马L.种子提取物显示了针对呼吸道合胞病毒（RSV）的毒性和抗病毒活动，并减少了体内更新炎症的肺部

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摘要

Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease and bronchiolitis in children worldwide. No vaccine or specific, effective treatment is currently available. beta-escin is one of the main bioactive constituents of Aesculus hippocastanum L. (Hippocastanaceae) seed extract (AH), and both beta-escin and AH have demonstrated a beneficial role in clinical therapy because of their anti-edematous, anti-inflammatory and antioxidative effects. Besides, we have reported that beta-escin and AH show virucidal, antiviral and immunomodulatory activities against the enveloped viruses HSV-1, VSV and Dengue virus in vitro. In this study, we demonstrate that beta-escin and AH have virucidal and antiviral activities against RSV, as well as NF-kappa B, AP-1 and cytokine modulating activities in RSV infected epithelial and macrophage cell lines in vitro. Besides, in a murine model of pulmonary RSV infection, AH treatment improves the course of acute disease, evidenced by decreased weight loss, reduced RSV lung titers, and attenuated airway inflammation. In contrast, even though beta-escin showed, similarly to AH, antiviral and immunomodulatory properties in vitro, it neither reduces viral titers nor attenuates lung injury in vivo. Thus, our data demonstrate that AH restrains RSV disease through antiviral and immunomodulatory effect.
机译：呼吸道合胞病毒（RSV）是全世界儿童呼吸道疾病和支气管炎的主要原因。目前没有疫苗或特定的有效治疗。 Beta-Escin是艾西米/麦克马斯坦的主要生物活性成分之一（Hippocastanaceae）种子提取物（Ah），并且β-Escin和Ah均在临床治疗中表现出有益的作用，因为它们的抗水肿，抗炎和抗炎和抗氧化作用。此外，我们报告说，β-Escin和AH展示了对包膜病毒HSV-1，VSV和登革热病毒的毒性，抗病毒和免疫调节活动。在这项研究中，我们证明了β-Escin和AH对RSV的毒性和抗病毒活性，以及​​在体外RSV感染的上皮和巨噬细胞系中的NF-Kappa B，AP-1和细胞因子调节活性。此外，在肺部RSV感染的小鼠模型中，AH治疗改善了急性疾病的过程，减少减少，减少RSV肺滴度和减毒通风炎症，证明了急性疾病的过程。相比之下，即使β-Escin表现出类似于αH，抗病毒和免疫调节性质，既不会降低病毒滴度，也不减轻体内肺损伤。因此，我们的数据表明AH通过抗病毒和免疫调节效果抑制RSV疾病。

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