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首页> 外文期刊>Advanced drug delivery reviews >Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs.
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Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs.

机译：来自水溶性聚合物脂质衍生物的胶束，作为难溶性药物的递送系统。

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Polymeric micelles have a whole set of unique characteristics, which make them very promising drug carriers, in particular, for poorly soluble drugs. Our review article focuses on micelles prepared from conjugates of water-soluble polymers, such as polyethylene glycol (PEG) or polyvinyl pyrrolidone (PVP), with phospholipids or long-chain fatty acids. The preparation of micelles from certain polymer-lipid conjugates and the loading of these micelles with various poorly soluble anticancer agents are discussed. The data on the characterization of micellar preparations in terms of their morphology, stability, longevity in circulation, and ability to spontaneously accumulate in experimental tumors via the enhanced permeability and retention (EPR) effect are presented. The review also considers the preparation of targeted immunomicelles with specific antibodies attached to their surface. Available in vivo results on the efficiency of anticancer drugs incorporated into plain micelles and immunomicelles in animal models are also discussed.
机译：聚合胶束具有一整套独特的特性，这使其成为非常有前途的药物载体，尤其是对于难溶性药物。我们的综述文章集中于由水溶性聚合物（例如聚乙二醇（PEG）或聚乙烯吡咯烷酮（PVP））与磷脂或长链脂肪酸的共轭物制备的胶束。讨论了由某些聚合物-脂质缀合物制备胶束以及这些胶束负载各种难溶性抗癌剂的情况。提供了关于胶束制剂的形态，稳定性，循环寿命以及通过增强的通透性和保留（EPR）效应自发积累在实验肿瘤中的能力方面的表征数据。该综述还考虑了在其表面附着有特异性抗体的靶向免疫胶束的制备。还讨论了有关在动物模型中掺入普通胶束和免疫胶束的抗癌药效率的体内可用结果。

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