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首页> 外文期刊>Archives of dermatological research. >Decreased lysyl oxidase-like 2 expression in mid-dermal elastolysis.
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Decreased lysyl oxidase-like 2 expression in mid-dermal elastolysis.

机译：在中皮肤弹出中降低赖氨酸氧化酶样2表达。

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Mid-dermal elastolysis (MDE) is a rare disorder that is histopathologically characterized by selective loss of elastic fibres in the mid-dermis. Aetiopathogenesis of MDE is still obscure. We report for the first time on the expression of lysyl oxidase-like (LOXL) proteins in lesional and non-lesional skin of a patient with reticular variant of MDE. Real-time RT-PCR and immunohistochemistry were performed for matrix metalloproteinase-2 (MMP2), MMP7, MMP9, LOXL1, LOXL2, and LOXL3. LOXL1 and LOXL3 mRNA levels in lesional skin did not substantially differ from mRNA levels measured in healthy skin. For LOXL2, however, we found decreased mRNA expression in lesional skin as compared to healthy skin. mRNA expression of MMP2 and MMP7 of lesional skin did not substantially differ from healthy skin. However, MMP9 mRNA expression was massively increased in lesional skin when compared to healthy skin. Immunohistochemistry confirmed the altered expression of LOXL2 and MMP9 in lesional skin. In conclusion, our preliminary data suggest that not only increased elastolytic activity (e.g. MMP9 up-regulation) but also affected elastin renewal due to reduced LOXL expression may contribute to the pathogenesis of MDE. More research is warranted in MDE especially with regard to the LOX family, fibulins, fibrillins, and desmosines.
机译：中皮肤弹性分解（MDE）是一种罕见的混乱，其是通过在中部除尘器中的弹性纤维选择性损失的组织病理学的特征。 MDE的Aetiop病症仍然模糊不清。我们首次报告赖氨酸氧化酶样（LOX1）蛋白在具有网状变体的患者的损伤和非损伤皮肤中的表达。对基质金属蛋白酶-2（MMP2），MMP7，MMP9，LOXL1，LOX12和LOXL3进行实时RT-PCR和免疫组织化学。 LOX11和LOXL3损伤皮肤中的mRNA水平与健康皮肤中测量的mRNA水平没有显着不同。然而，对于LOX12，与健康皮肤相比，我们发现损害皮肤中的mRNA表达减少。 MMP2和损伤皮肤MMP7的mRNA表达与健康皮肤没有显着不同。然而，与健康皮肤相比，MMP9 mRNA表达在损害皮肤中大规模增加。免疫组织化学证实了LOXL2和MMP9在损伤皮肤中的改变表达。总之，我们的初步数据表明，不仅增加了弹性溶解活性（例如MMP9上调），而且由于降低的LOX1表达，也可能有助于MDE的发病机制。 MDE有关更多的研究，特别是关于LOX家族，纤维素，纤维蛋白和DESMOSINES。

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