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首页> 外文期刊>Archives of dermatological research. >Decreased lysyl oxidase-like 2 expression in mid-dermal elastolysis.
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Decreased lysyl oxidase-like 2 expression in mid-dermal elastolysis.

机译：真皮中溶酶的赖氨酰氧化酶样2表达减少。

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Mid-dermal elastolysis (MDE) is a rare disorder that is histopathologically characterized by selective loss of elastic fibres in the mid-dermis. Aetiopathogenesis of MDE is still obscure. We report for the first time on the expression of lysyl oxidase-like (LOXL) proteins in lesional and non-lesional skin of a patient with reticular variant of MDE. Real-time RT-PCR and immunohistochemistry were performed for matrix metalloproteinase-2 (MMP2), MMP7, MMP9, LOXL1, LOXL2, and LOXL3. LOXL1 and LOXL3 mRNA levels in lesional skin did not substantially differ from mRNA levels measured in healthy skin. For LOXL2, however, we found decreased mRNA expression in lesional skin as compared to healthy skin. mRNA expression of MMP2 and MMP7 of lesional skin did not substantially differ from healthy skin. However, MMP9 mRNA expression was massively increased in lesional skin when compared to healthy skin. Immunohistochemistry confirmed the altered expression of LOXL2 and MMP9 in lesional skin. In conclusion, our preliminary data suggest that not only increased elastolytic activity (e.g. MMP9 up-regulation) but also affected elastin renewal due to reduced LOXL expression may contribute to the pathogenesis of MDE. More research is warranted in MDE especially with regard to the LOX family, fibulins, fibrillins, and desmosines.
机译：真皮中弹力松解术（MDE）是一种罕见的疾病，其组织病理学特征是真皮中层弹性纤维的选择性丢失。 MDE的发病机理仍然不清楚。我们首次报道了MDE网状变异患者的病灶和非病灶皮肤中赖氨酰氧化酶样（LOXL）蛋白的表达。对基质金属蛋白酶2（MMP2），MMP7，MMP9，LOXL1，LOXL2和LOXL3进行实时RT-PCR和免疫组织化学。病变皮肤中的LOXL1和LOXL3 mRNA水平与健康皮肤中的mRNA水平没有实质性差异。但是，对于LOXL2，我们发现与健康皮肤相比，病变皮肤中的mRNA表达下降。病变皮肤的MMP2和MMP7的mRNA表达与健康皮肤没有实质性差异。但是，与健康皮肤相比，病变皮肤中的MMP9 mRNA表达大量增加。免疫组织化学证实了病变皮肤中LOXL2和MMP9表达的改变。总之，我们的初步数据表明，不仅LOSL表达降低，不仅增加了弹性活动（例如MMP9上调），而且还影响了弹性蛋白更新，可能有助于MDE的发病机理。在MDE中，有必要进行更多的研究，尤其是有关LOX家族，血纤蛋白，原纤蛋白和地高糖精的研究。

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