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首页> 外文期刊>Archives of dermatological research. >High-definition optical coherence tomography: adapted algorithmic method for pattern analysis of inflammatory skin diseases: a pilot study.
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High-definition optical coherence tomography: adapted algorithmic method for pattern analysis of inflammatory skin diseases: a pilot study.

机译：高清光学相干断层扫描：适应炎症皮肤病模式分析的适应算法方法：试验研究。

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High-definition optical coherence tomography (HD-OCT) is a non-invasive technique for morphological investigation of tissue with cellular resolution filling the imaging gap between reflectance confocal microscopy and conventional optical coherence tomography. The aim of this study is first to correlate dermatopathologic descriptors of inflammatory skin conditions with epidermal alteration to features observed by HD-OCT. Secondly, to assess the discriminative accuracy of common inflammatory reaction patterns with epidermal alteration using HD-OCT by applying Ackerman's algorithmic method of pattern recognition. The generated HD-OCT images of 160 patients presenting an inflammatory skin disease were analyzed with respect to the following criteria: visualization of individual cells in the epidermis and dermis and morphology of dermo-epidermal junction, papillary dermis and reticular dermis. A set of morphological features corresponding to dermatopathological descriptors are obtained and the discriminative accuracy of HD-OCT of inflammatory reaction patterns could be demonstrated. These patterns are spongiotic dermatitis, psoriasiform dermatitis, interface dermatitis and ballooning dermatitis. Additional studies to test the sensitivity and specificity of the proposed algorithm for pattern analysis are essential. The other categories of Ackerman's pattern recognition need to be evaluated. This study provides a set of morphological features generated by HD-OCT imaging very similar to those described for reflectance confocal microscopy but with the advantages not only to visualize individual cells up to a depth of 570 μm but also in both slice and en face mode. An adapted algorithmic method for pattern analysis of common inflammatory skin diseases could be proposed. This new technique appears to be a promising method for non-invasive diagnosis, evaluation and management of common inflammatory skin diseases.
机译：高清晰度光学相干断层扫描（HD-OCT）是一种非侵入性技术，用于填充反射轴聚谱与传统光学相干断层扫描之间的成像间隙的细胞分辨率的形态学研究。本研究的目的首先是将炎症性皮肤病的皮肤病描述符与表皮改变相关给HD-OCT观察到的特征。其次，通过应用Ackerman的模式识别算法方法评估使用HD-OCT的表皮改变的常见炎症反应模式的鉴别准确性。关于以下标准分析了患有炎症皮肤病的160例患者的生成的HD-OCT图像：表皮中单个细胞的可视化和皮肤表皮结，乳头状真皮和网状真皮的表皮和皮肤形态。获得了对应于皮肤病病理描述仪的一组形态特征，可以证明炎症反应模式的HD-OCT的辨别精度。这些模式是垂涎的皮肤炎，牛皮癣皮炎，界面皮炎和膨胀性皮炎。用于测试所提出的模式分析算法的敏感性和特异性的额外研究是必不可少的。需要评估其他类别的Ackerman模式识别。该研究提供了一系列由HD-OCT成像产生的一组形态特征，其非常类似于用于反射共聚焦显微镜的那些，但是不仅可以使单个细胞可视化为570μm的深度而且在两种切片和ZH面部模式中的优点。可以提出一种适应性炎症皮肤病模式分析的调整算法。这种新技术似乎是常见炎症皮肤病的非侵入性诊断，评估和管理的有希望的方法。

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