Circulating Free Methylated Tumor DNA Markers for Sensitive Assessment of Tumor Burden and Early Response Monitoring in Patients Receiving Systemic Chemotherapy for Colorectal Cancer Liver Metastasis

Bhangu Jagdeep Singh; Beer Andrea; Mittlboeck Martina; Tamandl Dietmar; Pulverer Walter; Schoenthaler Silvia; Taghizadeh Hossein; Stremitzer Stefan; Kaczirek Klaus; Gruenberger Thomas; Gnant Michael; Bergmann Michael; Mannhalter Christine; Weinhaeusel Andreas; Oehler Rudolf; Bachleitner-Hofmann Thomas

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Circulating Free Methylated Tumor DNA Markers for Sensitive Assessment of Tumor Burden and Early Response Monitoring in Patients Receiving Systemic Chemotherapy for Colorectal Cancer Liver Metastasis

机译：循环自由甲基化肿瘤DNA标志物，用于肿瘤负荷和早期反应监测敏感评估，接受整理癌细胞转移的全身化疗

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Background: Neoadjuvant chemotherapy (neoCTx) followed by hepatic resection is the treatment of choice for patients with colorectal cancer liver metastasis (CLM). Treatment response is generally assessed using radiologic imaging after several cycles of chemotherapy. However, earlier assessment of response would be desirable since nonresponders could be switched early to an alternative chemotherapy regimen. Recent evidence suggests that circulating free methylated tumor DNA is a highly sensitive biomarker and may more accurately reflect tumor burden and treatment response than conventional markers for CRC.

机译：背景：Neoadjuvant化疗（Neoctx），其次是肝切除术是对结直肠癌肝转移（CLM）患者的选择。在几次化疗后，通常使用放射学成像评估治疗响应。然而，早期对反应的评估是理想的，因为无反应者可以早期切换到替代化疗方案。最近的证据表明，循环游离甲基化肿瘤DNA是高敏感的生物标志物，并且可以更准确地反映肿瘤负荷和治疗响应而不是CRC的常规标志物。

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来源
《Annals of Surgery》 |2018年第5期|共9页
作者
Bhangu Jagdeep Singh; Beer Andrea; Mittlboeck Martina; Tamandl Dietmar; Pulverer Walter; Schoenthaler Silvia; Taghizadeh Hossein; Stremitzer Stefan; Kaczirek Klaus; Gruenberger Thomas; Gnant Michael; Bergmann Michael; Mannhalter Christine; Weinhaeusel Andreas; Oehler Rudolf; Bachleitner-Hofmann Thomas;
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作者单位

Med Univ Vienna Dept Surg Wahringer Gurtel 18-20 A-1090 Vienna Austria;

Med Univ Vienna Dept Pathol Vienna Austria;

Med Univ Vienna Ctr Med Stat Informat &

Intelligent Syst Vienna Austria;

Med Univ Vienna Dept Radiol Vienna Austria;

Austrian Inst Technol Vienna Austria;

Med Univ Vienna Dept Surg Wahringer Gurtel 18-20 A-1090 Vienna Austria;

Med Univ Vienna Dept Surg Wahringer Gurtel 18-20 A-1090 Vienna Austria;

Med Univ Vienna Dept Surg Wahringer Gurtel 18-20 A-1090 Vienna Austria;

Med Univ Vienna Dept Surg Wahringer Gurtel 18-20 A-1090 Vienna Austria;

Rudolfstiftung Hosp Dept Surg Vienna Austria;

Med Univ Vienna Dept Surg Wahringer Gurtel 18-20 A-1090 Vienna Austria;

Med Univ Vienna Clin Dept Med Vienna Austria;

Austrian Inst Technol Vienna Austria;

Rudolfstiftung Hosp Dept Surg Vienna Austria;

Med Univ Vienna Dept Surg Wahringer Gurtel 18-20 A-1090 Vienna Austria;

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原文格式 PDF
正文语种 eng
中图分类外科学;
关键词
colorectal liver metastasis; liquid biopsy; methylated tumor DNA; prediction of response; septin-9;

机译：结肠直肠肝转移;液体活检;甲基化肿瘤DNA;预测反应;SEDIN-9;

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专利

1. Circulating Free Methylated Tumor DNA Markers for Sensitive Assessment of Tumor Burden and Early Response Monitoring in Patients Receiving Systemic Chemotherapy for Colorectal Cancer Liver Metastasis [J] . Bhangu Jagdeep Singh, Beer Andrea, Mittlboeck Martina, Annals of Surgery . 2018,第5期

机译：循环自由甲基化肿瘤DNA标志物，用于肿瘤负荷和早期反应监测敏感评估，接受整理癌细胞转移的全身化疗
2. Mutational burden on circulating cell-free tumor-DNA testing as a surrogate marker of mismatch repair deficiency or microsatellite instability in patients with colorectal cancers [J] . Pashtoon Murtaza Kasi Journal of Gastrointestinal Oncology . 2017,第4期

机译：循环无细胞肿瘤DNA检测的突变负担作为大肠癌患者错配修复缺陷或微卫星不稳定性的替代标志
3. Circulating free plasma tumor DNA in patients with advanced gastric cancer receiving systemic chemotherapy [J] . Sávia Raquel Costa Normando, Pamela de Oliveira Delgado, Ana Katherine Soares Barbosa Rodrigues, BMC Clinical Pathology . 2018,第1期

机译：晚期胃癌患者接受全身化疗的循环游离血浆肿瘤DNA
4. Isolation of Circulating Tumor Cells from Patients with Metastatic Colorectal Cancer Using Label-Free Microfluidic Technology for Enumeration and Detection of KRAS, BRAF, PIK3CA Mutation [C] . Haiyan Emily Liu, Evelyn Kidess-Sigal, Melanie Triboulet, International Molecular Medicine Tri-Conference. . 2016

机译：使用无标记微流体技术分离转移性结肠直肠癌患者的循环肿瘤细胞进行募准和检测KRA，BRAF，PIK3CA突变
5. Comparative Analysis on Innate Immune System Function in Metastatic Breast, Colorectal, and Prostate Cancer Patients with Circulating Tumor Cells [D] . Santos, Mark Anthony Francisco. 2014

机译：转移性乳腺癌，结直肠癌和前列腺癌患者循环肿瘤细胞先天免疫系统功能的比较分析
6. Mutational burden on circulating cell-free tumor-DNA testing as a surrogate marker of mismatch repair deficiency or microsatellite instability in patients with colorectal cancers [O] . Pashtoon Murtaza Kasi 2017

机译：循环无细胞肿瘤DNA检测的突变负担作为大肠癌患者错配修复缺陷或微卫星不稳定性的替代标志
7. Circulating free plasma tumor DNA in patients with advanced gastric cancer receiving systemic chemotherapy [O] . Sávia Raquel Costa Normando, Pamela de Oliveira Delgado, Ana Katherine Soares Barbosa Rodrigues, 2018

机译：循环自由血浆肿瘤DNA患者治疗全身化疗的晚期胃癌

Circulating Free Methylated Tumor DNA Markers for Sensitive Assessment of Tumor Burden and Early Response Monitoring in Patients Receiving Systemic Chemotherapy for Colorectal Cancer Liver Metastasis

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