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首页> 外文期刊>Advanced drug delivery reviews >Anaerobic metabolism and quorum sensing by Pseudomonas aeruginosa biofilms in chronically infected cystic fibrosis airways: rethinking antibiotic treatment strategies and drug targets.
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Anaerobic metabolism and quorum sensing by Pseudomonas aeruginosa biofilms in chronically infected cystic fibrosis airways: rethinking antibiotic treatment strategies and drug targets.

机译：铜绿假单胞菌生物膜在慢性感染的囊性纤维化气道中的无氧代谢和定额感应：对抗生素治疗策略和药物靶点的重新思考。

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Recent evidence indicates that Pseudomonas aeruginosa residing as biofilms in airway mucus of cystic fibrosis (CF) patients is undergoing anaerobic metabolism, a form of growth requiring gene products that are not utilized during aerobic growth. The outer membrane protein, OprF, and the rhl quorum sensing circuit are two previously unrecognized cellular factors that are required for optimal anaerobic biofilm viability. Without OprF, bacteria grow extremely poorly because they lack nitrite reductase activity while lacking rhlR or rhlI forces bacteria to undergo metabolic suicide by overproduction of nitric oxide. Furthermore, anaerobic growth favors maintenance of the mucoid, alginate-overproducing phenotype. Thus, with increasing age of CF patients, mucoid populations predominate, indicating that anaerobic bacteria reside in the inspissated airway mucus. Because many frontline antibiotics used in the treatment of CF airway disease are either ineffective or show reduced efficacy during anaerobic conditions, we propose development of new drugs to combat anaerobic metabolism by P. aeruginosa for more effective treatment of chronic CF lung infections.
机译：最近的证据表明，作为囊性纤维化（CF）患者气道粘液中生物膜的绿脓杆菌正在经历无氧代谢，这种增长形式需要在有氧生长过程中不使用的基因产物。外膜蛋白OprF和rhl群体感应电路是两个之前无法识别的细胞因子，它们是最佳厌氧生物膜生存能力所必需的。如果没有OprF，细菌的生长将极差，因为它们缺乏亚硝酸还原酶的活性，而缺乏rhlR或rhlI则使细菌由于一氧化氮的过量产生而遭受新陈代谢的自杀。此外，厌氧生长有利于维持粘液样，藻酸盐过量产生表型。因此，随着CF患者年龄的增加，粘液样种群占主导，这表明厌氧细菌存在于呼吸道粘液中。由于许多用于治疗CF气道疾病的一线抗生素在无氧条件下要么无效，要么显示功效降低，因此我们建议开发新的抗铜绿假单胞菌厌氧代谢的药物，以更有效地治疗慢性CF肺部感染。

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