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Current challenges in non-invasive insulin delivery systems: A comparative review

机译:非侵入性胰岛素输送系统中的当前挑战:比较评论

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摘要

The quest to eliminate the needle from insulin delivery and to replace it with non- or less-invasive alternative routes has driven rigorous pharmaceutical research to replace the injectable forms of insulin. Recently, various approaches have been studied involving many strategies using various technologies that have shown success in delivering insulin, which are designed to overcome the inherent barriers for insulin uptake across the gastrointestinal tract, mucosal membranes and skin. This review examines some of the many attempts made to develop alternative, more convenient routes for insulin delivery to avoid existing long-term dependence on multiple subcutaneous injections and to improve the pharmacodynamic properties of insulin. In addition, this article concentrates on the successes in this new millennium in developing potential non-invasive technologies and devices, and on major new milestones in modern insulin delivery for the effective treatment of diabetes.
机译:寻求从胰岛素输送中消除针头并用非侵入性或微创性替代途径替代针头的需求推动了严格的药物研究,以替代胰岛素的可注射形式。近来,已经研究了各种方法,这些方法涉及使用各种技术的多种策略,这些技术已显示出成功递送胰岛素的目的,这些技术旨在克服胰岛素通过胃肠道,粘膜和皮肤吸收的固有障碍。这篇综述检查了为开发替代的,更方便的胰岛素输送途径而进行的许多尝试中的一些尝试,以避免现有的长期依赖于多次皮下注射并改善胰岛素的药效特性。此外,本文着眼于新千年在开发潜在的非侵入性技术和设备方面的成功,以及现代胰岛素有效治疗糖尿病的重要新里程碑。

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