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首页> 外文期刊>Acta tropica: Journal of Biomedical Sciences >Thalidomide influences the function of macrophages and increases the survival of Plasmodium berghei-infected CBA mice.
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Thalidomide influences the function of macrophages and increases the survival of Plasmodium berghei-infected CBA mice.

机译：沙利度胺影响巨噬细胞的功能并增加感染伯氏疟原虫的CBA小鼠的存活。

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摘要

Malaria remains a major cause of morbidity and mortality in vast areas of the world, mainly due to the severe forms of Plasmodium falciparum infection. The exacerbated immune response, with increased production of TNF and reactive nitrogen and oxygen intermediates, plays a role in the complex pathogenesis of the disease. It is recognised that thalidomide decreases TNF production and may modulate several functions of the immune system. This work evaluated the influence of thalidomide on macrophage functions, and its ability to protect against severe disease. Plasmodium berghei ANKA-infected mice were (n=11) or were not (n=10) intra-gastric treated with thalidomide (150 mg/kg per day), and two other control groups not infected with the parasite were (n=8) or were not (n=10) treated with the drug, and macrophage production of hydrogen peroxide and nitric oxide, and phagocytosis were assessed on the eighth day post-infection. Thalidomide increased the survival time of infected mice, in parallel with a 26.5% increase of the mean of macrophage phagocytic index, and augmented in 13% the mean of the production of hydrogen peroxide and in 45% the mean of nitric oxide production by macrophages related to the non-treated P. berghei-infected mice. Our data indicate that thalidomide improves the outcome of P. berghei ANKA-infected CBA mice and suggest that this drug could represent a new alternative to be associated to antimalarial drugs to decrease the morbidity and mortality of severe malaria in non-pregnant individuals.
机译：疟疾仍然是世界广大地区发病和死亡的主要原因，主要是由于恶性疟原虫感染的严重形式。随着TNF和活性氮和氧中间体的产生增加，加剧的免疫反应在该疾病的复杂发病机理中起作用。公认沙利度胺降低TNF的产生并可能调节免疫系统的几种功能。这项工作评估了沙利度胺对巨噬细胞功能的影响及其抵抗严重疾病的能力。经沙利度胺（每天150 mg / kg）胃内治疗的伯氏疟原虫ANKA感染的小鼠（n = 11）或未进行胃内治疗（n = 10），另两个未感染寄生虫的对照组为（n = 8） ）或未进行过（n = 10）的药物治疗，在感染后第八天评估了巨噬细胞产生过氧化氢和一氧化氮以及吞噬作用。沙利度胺增加了感染小鼠的存活时间，同时使巨噬细胞吞噬指数的平均值增加了26.5％，并使过氧化氢产生的平均值增加了13％，与巨噬细胞相关的一氧化氮的产生平均值增加了45％对未经治疗的伯氏疟原虫感染的小鼠。我们的数据表明，沙利度胺可改善感染伯氏疟原虫ANKA的CBA小鼠的结局，并表明该药物可能代表一种与抗疟药相关的新替代品，以降低非孕妇个体中严重疟疾的发病率和死亡率。

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