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首页> 外文期刊>Archives of microbiology >Comparative transcriptome analysis of Trueperella pyogenes reveals a novel antimicrobial strategy
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Comparative transcriptome analysis of Trueperella pyogenes reveals a novel antimicrobial strategy

机译：Trueperella pyogenes的比较转录组分析显示了一种新的抗微生物策略

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摘要

Trueperella pyogenes is a prevalent opportunistic bacterium that normally causes diverse suppurative lesions, endometritis and pneumonia in various economically important animals. Although the genomic information of this species has been announced, little is known about its functional profiles. In this study, by performing a comparative transcriptome analysis between the highly and moderately virulent T. pyogenes isolates, we found the expression of a LuxR-type DNA-binding response regulator, PloR, was significantly up-regulated in the highly virulent T. pyogenes. Protein crystal structure prediction and primary functional assessment suggested that, the quorum-sensing signal molecules of Gram-negative bacteria such as Pseudomonas aeruginosa and Escherichia coli could significantly inhibit the growth, biofilm production and hemolysis of T. pyogenes by binding to the upstream sensor histidine kinase, PloS. Therefore, the PloS/PlosR two-component regulatory system might dominate the virulence of T. pyogenes. Our findings provide a major advance in understanding the pathogenesis of T. pyogenes, and may shed new light on the development of novel therapeutic strategies to control T. pyogenes infection.
机译：Trueperella pyogenes是一种普遍的机会性细菌，通常导致各种经济上重要的动物中的多种化脓性病变，子宫内膜炎和肺炎。虽然已经公布了该物种的基因组信息，但对于其功能性谱而言，毫无疑问。在这项研究中，通过在高度和中等毒性的T. pyogenes的比较转录组分析中，我们发现Luxr型DNA结合响应调节剂的表达在高毒力的T. pyogenes中显着上调。蛋白质晶体结构预测和主要功能评估表明，通过与上游传感器组氨酸结合激酶，Plos。因此，PLOS / PLOSR双组分调节系统可能使T. pyogenes的毒力占主导地位。我们的调查结果提供了了解理解T. pyogenes的发病机制，并且可以对控制T. pyogenes感染的新的治疗策略的发展进行新的光明。

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  • 来源
    《Archives of microbiology》 |2017年第5期|共7页
  • 作者

    Zhao Kelei; Li Wujiao; Huang Ting; Song Xuhao; Zhang Xiuyue; Yue Bisong;

  • 作者单位

    Sichuan Univ Key Lab Bioresources &

    Ecoenvironm Minist Educ Coll Life Sci Chengdu 610064;

    Sichuan Univ Key Lab Bioresources &

    Ecoenvironm Minist Educ Coll Life Sci Chengdu 610064;

    Sichuan Univ Key Lab Bioresources &

    Ecoenvironm Minist Educ Coll Life Sci Chengdu 610064;

    Sichuan Univ Key Lab Bioresources &

    Ecoenvironm Minist Educ Coll Life Sci Chengdu 610064;

    Sichuan Univ Key Lab Bioresources &

    Ecoenvironm Minist Educ Coll Life Sci Chengdu 610064;

    Sichuan Univ Sichuan Key Lab Conservat Biol Endangered Wildlif Coll Life Sci 24 South Sect 1;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 微生物学;
  • 关键词

    Trueperella pyogenes; Transcriptome; Virulence; Two-component regulatory system;

    机译：Trueperella pyogenes;转录组;毒力;双组分监管系统;

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