Topical application of ointment containing 0.5% green tea catechins suppresses tongue oxidative stress in 5-fluorouracil administered rats

Hisataka Miyai; Takayuki Maruyama; Takaaki Tomofuji; Toshiki Yoneda; Tetsuji Azuma; Hirofumi Mizuno; Yoshio Sugiura; Terumasa Kobayashi; Daisuke Ekuni; Manabu Morita

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Topical application of ointment containing 0.5% green tea catechins suppresses tongue oxidative stress in 5-fluorouracil administered rats

机译：含有0.5％绿茶儿茶素的软膏的局部施用抑制了5-氟尿嘧啶的大鼠舌苔氧化胁迫

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Highlights ? Oral mucositis is one of the side effect in administration of 5-fluorouracil. ? Oxidative stress induced by 5-fluorouracil is an initiator of oral mucositis. ? Catechins have antioxidant activity. ? Catechins could prevent oxidative stress, with up-regulating Nrf2 signaling pathway. Abstract Objective The purpose of this study was to investigate the preventive effects of topical application of green tea catechins on tongue oxidative stress induced by 5-fluorouracil (5-FU) administration in rats. Design Male Wistar rats (n = 28, 8 weeks old) were divided into four groups of seven rats each: a negative control group (saline administration and application of ointment without green tea catechins), a positive control group (5-FU administration and application of ointment without green tea catechins), and two experimental groups (5-FU administration and application of ointment containing 0.1% or 0.5% green tea catechins). Topical application of each ointment to the ventral surface of the tongue was performed once a day for 5 days. The level of 8-hydroxydeoxyguanosine (8-OHdG) was determined to evaluate oxidative stress. Fluorescence staining was also performed to confirm nuclear factor erythroid 2-related factor 2 (Nrf2) translocation to the nucleus. Results After the experimental period, the ratios of 8-OHdG-positive cells in the ventral tongue tissue were higher in the positive control group than in the negative control group ( P 0.05). On the other hand, those in the 0.5% green tea catechin group, but not in the 0.1% green tea catechin group, were lower than the positive control group ( P 0.05). In addition, Nrf2 translocation to the nucleus was greater in the 0.5% green tea catechin group than in the positive control group ( P 0.05). Conclusions Topical application of ointment containing 0.5% green tea catechins could prevent tongue oxidative stress in 5-FU administered rats, via up-regulation of the Nrf2 signaling pathway.

机译：强调？口腔粘膜炎是施用5-氟尿嘧啶的副作用之一。还由5-氟尿嘧啶诱导的氧化应激是口服粘液炎的引发剂。还儿茶素具有抗氧化活性。还儿茶素可以预防氧化应激，用上调NRF2信号通路。摘要本研究的目的是探讨绿茶儿茶素局部应用对大鼠5-氟尿嘧啶（5-FU）给药诱导的舌苔氧化应激的预防效果。设计雄性Wistar大鼠（n = 28,8周龄）分为四组七只大鼠：阴性对照组（盐碱管理和软膏的应用，没有绿茶儿茶素），阳性对照组（5-FU管理和软膏的应用不含绿茶儿茶素）和两组实验组（5-FU管理和含有0.1％或0.5％绿茶儿茶素的软膏的施用）。每个软膏对舌腹表面的局部施用一次每天进行5天。确定了8-羟基氧基胍（8-OHDG）的水平评价氧化应激。还进行荧光染色以确认核因子红外2相关因子2（NRF2）易位与细胞核。结果在实验期后，腹舌组织中的8-OHDG阳性细胞的比例在阳性对照组中比阴性对照组更高（P <0.05）。另一方面，0.5％绿茶儿茶素组的那些，但不在0.1％绿茶儿茶素组中，低于阳性对照组（P <0.05）。另外，在0.5％绿茶儿茶素组中，NRF2易位大于阳性对照组（P <0.05）。结论通过NRF2信号通路的上调，含有0.5％绿茶儿茶素的软膏的局部施用含有0.5％的绿茶儿茶素可以防止舌剂氧化应激。

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来源
《Archives of Oral Biology》 |2017年第2017期|共9页
作者
Hisataka Miyai; Takayuki Maruyama; Takaaki Tomofuji; Toshiki Yoneda; Tetsuji Azuma; Hirofumi Mizuno; Yoshio Sugiura; Terumasa Kobayashi; Daisuke Ekuni; Manabu Morita;
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作者单位

Department of Preventive Dentistry Okayama University Graduate School of Medicine Dentistry and;

Center for Innovative Clinical Medicine Okayama University Hospital;

Department of Community Oral Health Asahi University School of Dentistry;

Department of Preventive Dentistry Okayama University Graduate School of Medicine Dentistry and;

Department of Preventive Dentistry Okayama University Graduate School of Medicine Dentistry and;

Department of Preventive Dentistry Okayama University Graduate School of Medicine Dentistry and;

Department of Preventive Dentistry Okayama University Graduate School of Medicine Dentistry and;

Department of Preventive Dentistry Okayama University Graduate School of Medicine Dentistry and;

Department of Preventive Dentistry Okayama University Graduate School of Medicine Dentistry and;

Department of Preventive Dentistry Okayama University Graduate School of Medicine Dentistry and;

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正文语种 eng
中图分类口腔科学;
关键词
Antioxidant capacity; Chemotherapy; Green tea catechin; Oxidative stress; Tongue;

机译：抗氧化能力;化疗;绿茶儿茶素;氧化应激;舌头;

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1. Topical application of ointment containing 0.5% green tea catechins suppresses tongue oxidative stress in 5-fluorouracil administered rats [J] . Hisataka Miyai, Takayuki Maruyama, Takaaki Tomofuji, Archives of Oral Biology . 2017,第期

机译：含有0.5％绿茶儿茶素的软膏的局部施用抑制了5-氟尿嘧啶的大鼠舌苔氧化胁迫
2. Scientific Opinion on the substantiation of health claims related to Camellia sinensis (L.) Kuntze (tea), including catechins in green tea, and improvement of endothelium‐dependent vasodilation (ID 1106, 1310), maintenance of normal blood pressure (ID 1310, 2657), maintenance of normal blood glucose concentrations (ID 1108), maintenance of normal blood LDL cholesterol concentrations (ID 2640), protection of the skin from UV‐induced (including photo‐oxidative) damage (ID 1110, 1119), protection of DNA from oxidative damage (ID 1120, 1121), protection of lipids from oxidative damage (ID 1275), contribution to normal cognitive function (ID 1117, 2812), “cardiovascular system” (ID 2814), “invigoration of the body” (ID 1274, 3280), decreasing potentially pathogenic gastro‐intestinal microorganisms (ID 1118), “immune health” (ID 1273) and “mouth” (ID 2813) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 [J] . EFSA Journal . 2011,第4期

机译：关于证实茶花茶（Camelelli sinensis（L.）Kuntze）（包括绿茶中的儿茶素）的健康主张的科学意见，以及改善内皮依赖性血管舒张（ID 1106，1310），维持正常血压（ID 1310， 2657），维持正常血糖浓度（ID 1108），维持正常血液LDL胆固醇浓度（ID 2640），保护皮肤免受紫外线（包括光氧化）损害（ID 1110、1119），来自氧化损伤的DNA（ID 1120、1121），保护脂质免受氧化损伤（ID 1275），对正常认知功能的贡献（ID 1117、2812），“心血管系统”（ID 2814），“机体活力”（ ID 1274、3280），根据第1924/2006号法规（EC）第13（1）条，减少潜在的致病性胃肠道微生物（ID 1118），“免疫健康”（ID 1273）和“口”（ID 2813）
3. Green tea catechins ameliorate adipose insulin resistance by improving oxidative stress [J] . YanJ., ZhaoY., SuoS., Free Radical Biology and Medicine: The Official Journal of the Oxygen Society . 2012,第9期

机译：绿茶儿茶素通过改善氧化应激改善脂肪胰岛素抵抗
4. Effect of green tea catechins on oxidative DNA damage of hamster pancreas and liver induced by N-Nitrosobis(2-oxopropyl)amine and/or oxidized soybean oil [C] . Fumiyo Takabayashi, Shoichi Tahara, Takao Kaneko, International Conference on Food Factors . 2004

机译：绿茶儿茶素对N-硝基菌（2-氧丙基）胺和/或氧化大豆油诱导的仓鼠胰腺和肝脏氧化DNA损伤的影响
5. Effects of chronic green tea flavonoid supplementation on features of metabolic syndrome, biomarkers of oxidative stress and inflammation and plasma catechin levels in subjects with metabolic syndrome. [D] . Penugonda, Kavitha. 2009

机译：长期补充绿茶类黄酮对代谢综合征患者代谢综合征的特征，氧化应激和炎症的生物标志物以及血浆儿茶素水平的影响。
6. Applications of a Standardized Green Tea Catechin Preparation for Viral Warts and Human Papilloma Virus-Related and Unrelated Cancers [O] . Noriyuki Miyoshi, Hiroki Tanabe, Takuji Suzuki, 2020

机译：标准化绿茶儿茶素制剂在病毒性疣和人类乳头瘤病毒相关及无关癌症中的应用
7. Green tea with a high catechin content suppresses inflammatory cytokine expression in the galactosamine-injured rat liver [O] . Kouichi ABE, Mitsuhiro IJIRI, Takuji SUZUKI, 2005

机译：具有高儿茶素含量的绿茶抑制了半乳糖胺损伤的大鼠肝脏中的炎症细胞因子表达

Topical application of ointment containing 0.5% green tea catechins suppresses tongue oxidative stress in 5-fluorouracil administered rats

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