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首页> 外文期刊>Acta tropica: Journal of Biomedical Sciences >Characterizing longitudinal changes in rabbit brains infected with Angiostrongylus Cantonensis based on diffusion anisotropy
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Characterizing longitudinal changes in rabbit brains infected with Angiostrongylus Cantonensis based on diffusion anisotropy

机译：基于扩散各向异性表征感染广州管圆线虫的兔脑的纵向变化

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Angiostrongylus cantonensis has become a global source of infection in recent years, and the differential diagnosis and timely follow-up are crucial in the management of the infection. Magnetic resonance imaging (MRI) has been suggested as a non-invasive technique in characterizing and localizing lesions during the parasitic infections in the brain. Non-invasive diffusion tensor imaging (DTI) can be used to distinguish microscopic cerebral structures but cannot resolve the more complicated neural structure. Several methods have been proposed to overcome this limitation. One such method, generalized q-sampling imaging (GQI), can be applied to a variety of datasets, including the single shell, multi-shell or grid sampling schemes, which are believed to resolve complicated crossing fibers. This study aimed to characterize angiostrongyliasis in the rabbit brain over a 6-week period using anatomical and diffusion MRI, including DTI and GQI. Our anatomical T2WI and R2 mapping results showed that the ventricle size of the rabbit brain increased after A. cantonensis larvae infection, and the DTI and GQI indices both showed pathological changes in the corpus callosum, hippocampus and cortex over a 6-week infection period. These results were consistent with our histopathological findings. Our results demonstrated that the diagnosis of larvae infection using anatomical and diffusion MRI is possible and that follow-up characterization is informative in revealing the effects of angiostrongyliasis in various brain areas. These support the use of anatomical and diffusion MRI was helpful for diagnosis of eosinophilic meningitis caused by A. cantonensis infection. This non-invasive MRI platform could be used to improve the management of eosinophilic meningitis or eosinophilic meningoencephalitis in humans. (C) 2016 Elsevier B.V. All rights reserved.
机译：近年来，广州管圆线虫已成为全球感染源，鉴别诊断和及时随访对于感染的管理至关重要。磁共振成像（MRI）已被建议作为一种非侵入性技术来表征和定位脑部寄生虫感染期间的病变。非侵入性扩散张量成像（DTI）可用于区分微观的大脑结构，但不能解析更复杂的神经结构。已经提出了几种方法来克服该限制。一种这样的方法，广义q采样成像（GQI），可以应用于各种数据集，包括单壳，多壳或网格采样方案，据信它们可以解决复杂的交叉纤维。这项研究旨在使用解剖和扩散MRI（包括DTI和GQI）在6周的时间内表征兔脑血管毛细血管增多症。我们的解剖学T2WI和R2作图结果表明，在广州曲霉幼虫感染后，兔脑的脑室大小增加，并且DTI和GQI指数均显示在6周的感染期内period体，海马体和皮质的病理变化。这些结果与我们的组织病理学结果一致。我们的结果表明，使用解剖和扩散MRI诊断幼虫感染是可能的，并且后续的特征分析可揭示血管平滑肌病在各个脑区的作用。这些支持解剖和弥散MRI的使用，有助于诊断由广州A.感染引起的嗜酸性脑膜炎。该非侵入性MRI平台可用于改善人类嗜酸性粒细胞脑膜炎或嗜酸性粒细胞脑膜炎的管理。 （C）2016 Elsevier B.V.保留所有权利。

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