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首页> 外文期刊>Archives of Toxicology >E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE(-/-) mouse model
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E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE(-/-) mouse model

机译：在Apoe（/ - ）小鼠模型中6个月内吸入后，E-Vapor气溶胶不会影响骨烟雾相对于香烟烟雾

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摘要

Cigarette smoke (CS) exposure is one of the leading risk factors for human health. Nicotine-containing inhalable products, such as e-cigarettes, can effectively support tobacco harm reduction approaches. However, there are limited comparative data on the effects of the aerosols generated from electronic vapor products (e-vapor) and CS on bone. Here, we report the effects of e-vapor aerosols and CS on bone morphology, structure, and strength in a 6-month inhalation study. Eight-week-old ApoE(-/-) mice were exposed to aerosols from three different e-vapor formulations-CARRIER (propylene glycol and vegetable glycerol), BASE (CARRIER and nicotine), TEST (BASE and flavor)-to CS from 3R4F reference cigarettes at matched nicotine concentrations (35 mu g/L) or to fresh air (Sham) (N = 10 per group). Tibiae were analyzed for bone morphology by mu CT imaging, biomechanics by three-point bending, and by histological analysis. CS inhalation caused a significant decrease in cortical and total bone volume fraction and bone density relative to e-vapor aerosols. Additionally, CS exposure caused a decrease in ultimate load and stiffness. In contrast, bone structural and biomechanical parameters were not significantly affected by e-vapor aerosol or Sham exposure. At the dissection time point, there was no significant difference in body weight or tibia bone weight or length among the groups. Histological findings revealed microcracks in cortical bone areas among all exposed groups compared to Sham control. In conclusion, because of the bone-preserving effect of e-vapor aerosols relative to CS exposure, e-vapor products could potentially constitute less harmful alternatives to cigarettes in situations in which bone health is of importance.
机译：香烟烟雾（CS）曝光是人类健康的主要风险因素之一。含有尼古丁的可吸入产品，如电子烟，可以有效地支持烟草损害削减方法。然而，关于从电子蒸汽产物（E-VALOP）和骨骼上的CS产生的气溶胶效果有限的比较数据。在这里，我们在6个月的吸入研究中报告了电子蒸气气溶胶和Cs对骨形态，结构和强度的影响。将八周的Apoe（ - / - ）小鼠暴露于来自三种不同的E-蒸气配方 - 载体（丙二醇和蔬菜甘油），碱（载体和尼古丁），试验（碱和味道）-CS中的气溶胶在匹配的尼古丁浓度（35μg/ l）或新鲜空气（假）（每组n = 10）时，3R4F参考香烟。通过Mu CT成像，生物力学通过三点弯曲和组织学分析分析胫骨。 CS吸入导致皮质和总骨体积分数和相对于电子蒸汽气溶胶的骨密度的显着降低。另外，CS暴露导致最终负载和刚度降低。相比之下，骨结构和生物力学参数没有受到电子蒸汽气溶胶或假暴露的显着影响。在解剖时间点，对组中的体重或胫骨重量或长度没有显着差异。组织学发现，与假对照相比，所有暴露组的皮质骨区域中的微裂纹都揭示了皮质骨区域。总之，由于电子蒸气气溶胶相对于CS暴露的骨保留效果，E-Vapor产品可能构成骨骼健康重要性的卷烟的较少有害的替代品。

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