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首页> 外文期刊>Archives of Toxicology >Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation
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Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation

机译：异黄酮对人类乳腺组织和甲状腺激素体系的影响：全面的安全评价

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摘要

Isoflavones are secondary plant constituents of certain foods and feeds such as soy, linseeds, and red clover. Furthermore, isoflavone-containing preparations are marketed as food supplements and so-called dietary food for special medical purposes to alleviate health complaints of peri- and postmenopausal women. Based on the bioactivity of isoflavones, especially their hormonal properties, there is an ongoing discussion regarding their potential adverse effects on human health. This review evaluates and summarises the evidence from interventional and observational studies addressing potential unintended effects of isoflavones on the female breast in healthy women as well as in breast cancer patients and on the thyroid hormone system. In addition, evidence from animal and in vitro studies considered relevant in this context was taken into account along with their strengths and limitations. Key factors influencing the biological effects of isoflavones, e.g., bioavailability, plasma and tissue concentrations, metabolism, temporality (pre- vs. postmenopausal women), and duration of isoflavone exposure, were also addressed. Final conclusions on the safety of isoflavones are guided by the aim of precautionary consumer protection.
机译：异黄酮是某些食物和饲料的二级植物成分，如大豆，亚麻籽和红色三叶草。此外，含异黄酮的制剂作为食品补充剂和所谓的饮食食品为特殊的医疗目的而放缓，以减轻脑后和绝经后妇女的健康投诉。基于异黄酮的生物活性，尤其是它们的荷尔蒙属性，持续讨论其对人类健康的潜在不利影响。该审查评估并总结了介入和观察研究的证据，这些研究解决了异黄酮对健康妇女的女性乳腺以及乳腺癌患者和甲状腺激素系统的潜在意想不到的患者的潜在意想不到的影响。此外，考虑到在这种情况下认为相关的动物和体外研究的证据及其优势和局限性。还解决了影响异黄酮生物学效应的关键因素，例如生物利用度，血浆和组织浓度，代谢，暂时性（预后患者前期妇女）和异黄酮暴露的持续时间。关于异黄酮的安全的最终结论是以预防消费者保护的目标为指导。

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  • 来源
    《Archives of Toxicology》 |2018年第9期|共46页
  • 作者

    S. Hüser; S. Guth; H. G. Joost; S. T. Soukup; J. K?hrle; L. Kreienbrock; P. Diel; D. W. Lachenmeier; G. Eisenbrand; G. Vollmer; U. N?thlings; D. Marko; A. Mally; T. Grune; L. Lehmann; P. Steinberg; S. E. Kulling;

  • 作者单位

    Institute for Food Toxicology Senate Commission on Food Safety University of Veterinary Medicine;

    Institute for Food Toxicology Senate Commission on Food Safety University of Veterinary Medicine;

    Department of Experimental Diabetology German Institute of Human Nutrition (DIfE);

    Department of Safety and Quality of Fruit and Vegetables Max Rubner-Institut Federal Research;

    Institut für Experimentelle Endokrinologie Charité-Universit?tsmedizin Berlin Corporate Member of;

    Department of Biometry Epidemiology and Information Processing University of Veterinary Medicine;

    Department of Molecular and Cellular Sports Medicine Institute of Cardiovascular Research and;

    Chemisches und Veterin?runtersuchungsamt Karlsruhe;

    Division of Food Chemistry and Toxicology Molecular Nutrition Department of Chemistry Technische;

    Department of Biology Molecular Cell Physiology and Endocrinology Technische Universit?t Dresden;

    Department of Nutrition and Food Sciences Nutritional Epidemiology Rheinische Friedrich-Wilhelms;

    Department of Food Chemistry and Toxicology Faculty of Chemistry University of Vienna;

    Department of Toxicology University of Würzburg;

    Department of Molecular Toxicology German Institute of Human Nutrition (DIfE);

    Department of Food Chemistry Institute for Pharmacy and Food Chemistry University of Würzburg;

    Institute for Food Toxicology University of Veterinary Medicine Hannover;

    Department of Safety and Quality of Fruit and Vegetables Max Rubner-Institut Federal Research;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 毒物学（毒理学）;
  • 关键词

    Isoflavones; Human intervention studies; Observational studies; Breast tissue; Thyroid hormone system; Safety evaluation;

    机译：异黄酮;人类干预研究;观察研究;乳房组织;甲状腺激素系统;安全评估;

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