...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archives of Toxicology >A short-term inhalation study to assess the reversibility of sensory irritation in human volunteers
【24h】

A short-term inhalation study to assess the reversibility of sensory irritation in human volunteers

机译：短期吸入研究，以评估人类志愿者感官刺激的可逆性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sensory irritation is an acute adverse effect caused by chemicals that stimulate chemoreceptors of the upper respiratory tract or the mucous membranes of the outer eye. The avoidance of this end point is of uttermost importance in regulatory toxicology. In this study, repeated exposures to ethyl acrylate were analyzed to investigate possible carryover effects from day to day for different markers of sensory irritation. Thirty healthy subjects were exposed for 4 h on five subsequent days to ethyl acrylate at concentrations permitted by the German occupational exposure limit at the time of study. Ratings of eye irritation as well as eye blinking frequencies indicate the elicitation of sensory irritation. These markers of sensory irritation showed a distinct time course on every single day. However, cumulative carryover effects could not be identified across the week for any marker. The rhinological and biochemical markers could not reveal hints for more pronounced sensory irritation. Neither increased markers of neurogenic inflammation nor markers of immune response could be identified. Furthermore, the performance on neurobehavioral tests was not affected by ethyl acrylate and despite the strong odor of ethyl acrylate the participants improved their performances from day to day. While the affected physiological marker, the increased eye blinking frequency stays roughly on the same level across the week, subjective markers like perception of eye irritation decrease slightly from day to day though the temporal pattern of, i.e., eye irritation perception stays the same on each day. A hypothetical model of eye irritation time course derived from PK/PD modeling of the rabbit eye could explain the within-day time course of eye irritation ratings repeatedly found in this study more precisely.
机译：感觉刺激是由化学物质引起的急性不良影响，刺激上呼吸道的化学感受器或外眼的粘膜。避免这个终点在监管毒理学方面是最重要的。在该研究中，分析了对丙烯酸乙基乙酸乙酯的重复曝光，以对感官刺激的不同标志物的日常点来研究可能的携带效应。在研究时，在德国职业暴露限制允许的浓度下，在丙烯酸酯的五天内暴露4小时，在德国职业暴露限制在学习时的浓度下暴露4小时。眼睛刺激的评级以及眼睛闪烁频率表示感觉刺激的引发。这些感觉刺激的标记在每一天都显示出明显的时间路线。但是，对于任何标记，本周无法识别累积核算效应。泌尿过程和生化标记物不能透露暗示更明显的感官刺激。可以鉴定神经源性炎症或免疫应答标记的增加的标记。此外，神经兽性试验的性能不受丙烯酸乙酯的影响，尽管丙烯酸乙基乙基乙基乙基乙基乙烯酸乙酯，参与者将其表现从日常生活中提高。虽然受影响的生理标志，眼睛闪烁增加频率大致在本周的同一水平上，但是像对眼睛刺激的感知一样，虽然时间图案，但眼睛刺激感知的时间模式保持相同日。从兔眼的PK / PD模型衍生的眼睛刺激时间课程的假设模型可以更精确地解释在本研究中反复发现的眼睛刺激评级的日期内的日期。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号