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首页> 外文期刊>Archives of Toxicology >Toxicological assessment of magnesium oxide nanoparticles in HT29 intestinal cells
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Toxicological assessment of magnesium oxide nanoparticles in HT29 intestinal cells

机译：HT29肠细胞中氧化镁纳米粒子的毒理学评估

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摘要

Nanoparticles (NPs) are increasingly used in different consumer-related areas, for instance in food packaging or as additives, because of their enormous potential. Magnesium oxide (MgO) is an EU-approved food additive (E number 530). It is commonly used as a drying agent for powdered foods, for colour retention or as a food supplement. There are no consistent results regarding the effects of oral MgO NP uptake. Consequently, the aim of this study was to examine the effects of MgO NPs in the HT29 intestinal cell line. MgO NP concentrations ranged from 0.001 to 100 mu g/ml and incubation times were up to 24h. The cytotoxic and genotoxic potential were investigated. Apoptotic processes and cell cycle changes were analysed by flow cytometry. Finally, oxidative stress was examined. Transmission electron microscopy indicated that there was no cellular uptake. MgO NPs had no cytotoxic or genotoxic effects in HT29 cells and they did not induce apoptotic processes, cell cycle changes or oxidative stress.
机译：纳米颗粒（NPS）越来越多地用于不同的消费者相关区域，例如在食品包装或添加剂中，因为它们巨大的潜力。氧化镁（MgO）是欧盟批准的食品添加剂（E号530）。它通常用作粉末食品的干燥剂，用于颜色保留或作为食物补充剂。关于口腔MgO NP吸收的影响没有一致的结果。因此，本研究的目的是检查MgO NPS在HT29肠细胞系中的影响。 MgO NP浓度范围为0.001至100μg/ ml，孵育时间达24h。研究了细胞毒性和遗传毒性潜力。通过流式细胞术分析凋亡过程和细胞周期变化。最后，检查了氧化应激。透射电子显微镜表明没有细胞摄取。 MgO NPS在HT29细胞中没有细胞毒性或遗传毒性作用，并且它们没有诱导凋亡过程，细胞周期变化或氧化应激。

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