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首页> 外文期刊>ASAIO journal >Regional Cerebral Abnormalities Measured by Frequency-Domain Near-Infrared Spectroscopy in Pediatric Patients During Extracorporeal Membrane Oxygenation
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Regional Cerebral Abnormalities Measured by Frequency-Domain Near-Infrared Spectroscopy in Pediatric Patients During Extracorporeal Membrane Oxygenation

机译：通过体外膜氧合过程中儿科患者频率域近红外光谱测量的区域脑异常

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摘要

Extracorporeal membrane oxygenation (ECMO) is a form of advanced cardiorespiratory support provided to critically ill patients with severe respiratory or cardiovascular failure. While children undergoing ECMO therapy have significant risk for neurological morbidity, currently there is a lack of reliable bedside tool to detect the neurologic events for patients on ECMO. This study assessed the feasibility of frequency-domain near-infrared spectroscopy (NIRS) for detection of intracranial complications during ECMO therapy. The frequency-domain NIRS device measured the absorption coefficient (mu(a)) and reduced scattering coefficient (mu(s)') at six cranial positions from seven pediatric patients (0-16 years) during ECMO support and five healthy controls (2-14 years). Regional abnormalities in both absorption and scattering were identified among ECMO patients. A main finding in this study is that the abnormalities in scattering appear to be associated with lower-than-normal mu(s)' values in regional areas of the brain. Because light scattering originates from the intracellular structures (such as nuclei and mitochondria), a reduction in scattering primarily reflects loss or decreased density of the brain matter. The results from this study indicate a potential to use the frequency-domain NIRS as a safe and complementary technology for detection of intracranial complications during ECMO therapy.
机译：体外膜氧合（ECMO）是一种针对严重呼吸或心血管衰竭的患者提供的先进心肺患者的一种形式。虽然接受ECMO治疗的儿童具有显着性发病率的风险，但目前缺乏可靠的床头柜，以检测ECMO患者的神经系统事件。该研究评估了频域近红外光谱（NIR）用于检测ECMO治疗期间颅内并发症的可行性。频率域内NIRS装置测量吸收系数（MU（a））和六个小儿患者（0-16岁）的六个颅骨位置在ECMO支持和五个健康对照期间减少了散射系数（MU（S）'）（2 -14年）。在Ecmo患者中鉴定了吸收和散射的区域异常。本研究中的主要发现是散射的异常似乎与大脑区域地区的低于正常的MU（S）值相关联。因为光散射来自细胞内结构（如核和线粒体），所以散射的减少主要反映了大脑物质的密度损失或降低。本研究的结果表明，使用频率域内NIR作为在ECMO治疗期间检测颅内并发症的安全和互补技术的可能性。

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