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首页> 外文期刊>Arthritis and Rheumatism >Asspciation of Exercise Therapy and Reduction of Pain Sensitivity in Patients With Knee Osteoarthritis: A Randomized Controlled Trial
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Asspciation of Exercise Therapy and Reduction of Pain Sensitivity in Patients With Knee Osteoarthritis: A Randomized Controlled Trial

机译：膝关节骨关节炎患者的运动治疗和降低疼痛敏感性的协会：随机对照试验

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Objective. Exercise has beneficial effects on pain in knee osteoarthritis (OA), yet the underlying mechanisms are unclear. The purpose of this study was to investigate the effects of exercise on pressure-pain sensitivity in patients with knee OA. Methods. In a randomized controlled trial, participants were assigned to 12 weeks of supervised exercise therapy (ET; 36 sessions) or a no attention control group (CG). Pressure-pain sensitivity was assessed by cuff pressure algometry on the calf of the most symptomatic leg. The coprimary outcomes were pressure-pain thresholds (PPTs) and cumulated visual analog scale pain scores during constant pressure for 6 minutes at 125% of the PPT as a measure of temporal summation (TS) of pressure-pain. Secondary outcomes included self-reported pain using the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire. Analyses were based on the "per-protocol" population (participants following the protocol). Results. Sixty participants were randomized (31 in ET group, 29 in CG), and the per-protocol population included 48 participants (25 in ET group, 23 in CG). At followup, mean group differences in the change from baseline were 3.1 kPa (95% confidence interval [95% CI] 0.2, 6.0; P = 0.038) for the PPT, 2,608 mm X seconds (95% CI 458, 4,758; P = 0.019) for TS, and 6.8 points (95% CI 1.2, 12.4; P = 0.018) for KOOS pain, all in favor of ET. Conclusion. Pressure-pain sensitivity, TS, and self-reported pain are reduced among patients completing a 12-week supervised exercise program compared to a no attention CG. These results demonstrate beneficial effects of exercise on basic pain mechanisms and further exploration may provide a basis for optimized treatment.
机译：客观的。运动对膝关节骨关节炎（OA）疼痛有益的影响，但潜在的机制尚不清楚。本研究的目的是探讨运动对膝关节OA患者压力疼痛敏感性的影响。方法。在随机对照试验中，参与者被分配到12周的监督运动疗法（ET; 36次会议）或无注意控制组（CG）。通过袖口压态术来评估压力疼痛敏感性在最具症状腿部的小腿上的沟槽。组合结果是压力疼痛阈值（PPT），并且在恒定压力下累积的视觉模拟疼痛评分为6分钟，以125％的PPT作为压力疼痛的时间总和（TS）。二次结果包括使用膝关节损伤和骨关节炎结果评分（KOOS）问卷的自我报告的疼痛。分析基于“每协定”人口（协议后的参与者）。结果。六十名参与者随机（et组，CG中的31人），每议书人口包括48名参与者（25英寸ET组，23款）。在后续的情况下，PPT的基线变化的平均群体差异为3.1kPa（95％置信区间[95％ci] 0.2,6.0; p = 0.038），2,608 mm x秒（95％ci 458,4,758; p = 0.019）对于TS，6.8点（95％CI 1.2,12.4; p = 0.018），适用于ET。结论。与NO IMPERCG CG相比，完成12周监督运动计划的患者中，减少了压力疼痛敏感性，TS和自我报告的疼痛。这些结果表明，运动对基本疼痛机制的有益影响，进一步的探索可以为优化治疗提供依据。

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