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首页> 外文期刊>Asia Pacific journal of clinical nutrition >The effects of green kiwifruit combined with isoflavones on equol production, bone turnover and gut microflora in healthy postmenopausal women
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The effects of green kiwifruit combined with isoflavones on equol production, bone turnover and gut microflora in healthy postmenopausal women

机译：绿色猕猴桃与异黄酮相结合的效果对健康绝经后妇女的equol生产，骨质周转和肠道微生物

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Background and Objectives: Isoflavone (daidzein and genistein) interventions in postmenopausal women have produced inconsistent skeletal benefits, partly due to population heterogeneity in daidzein metabolism to equol by enteric bacteria. This study assessed changes in microflora and bone turnover in response to isoflavone and kiwifruit supplementation in New Zealand postmenopausal women. Methods and Study Design: Healthy women 1-10 years post-menopause were randomly allocated to group A (n = 16) or B (n = 17) for a 16-week crossover trial. Two consecutive 6-week treatment periods had a 2-week lead-in period at intervention commencement and a 2-week washout period between treatments. Treatments prescribed either (1) daily isoflavone supplementation (50 mg/day aglycone daidzein and genistein) alone, or (2) with two green kiwifruit. At treatment baseline and end-point (four time points) the serum bone markers C Telopeptide of Type I collagen (CTx), undercarboxylated osteocalcin (unOC), and serum and urinary daidzein and equol, were measured. Changes in gut microflora were monitored in a subgroup of the women. Results: Equol producers made up 30% of this study population (equol producers n = 10; non-equol producers n = 23) with serum equol rising significantly in equol producers. Serum ucOC decreased by 15.5% (p 0.05) after the kiwifruit and isoflavone treatment. There were no changes in serum CTx or in the diversity of the gut microflora. Conclusions: 50 mg/day isoflavones did not reduce bone resorption but kiwifruit and isoflavone consumption decreased serum ucOC levels, possibly due to vitamin K1 and/or other bioactive components of green kiwifruit.
机译：背景和目标：绝经后妇女的异黄酮（Daidzein和Genistein）干预措施产生了不一致的骨骼益处，部分原因是肠道细菌的Daidzein新陈代谢的群体异质性。该研究评估了微生物群和骨质扭转的变化，响应于新西兰绝经后妇女的异黄酮和猕猴桃补充剂。方法和研究设计：未经可能的妇女1-10岁，随机分配给A（n = 16）或B（n = 17），用于16周的交叉试验。连续两周的治疗期在干预开始时有2周的延期期和治疗之间的2周洗涤期。单独使用（1）每日异黄酮补充（50毫克/天糖苷糖苷Daidzinin和Genistein）的治疗，或（2）与两种绿色猕猴桃。在治疗基线和终点（四个时间点）测定I型胶原（CTX），底羧酸骨钙（UNOC）和血清和尿Daidzein和equol的血清骨标志物C细胞肽C细胞肽。在妇女的亚组中监测肠道微生物的变化。结果：EQUOL生产商占该研究人群的30％（Equol生产商n = 10;非equol生产商N = 23），血清Equol在Equol生产商中显着上升。在Kiwifruit和异黄酮处理后，血清UCOC降低了15.5％（P <0.05）。血清CTX或肠道微生物的多样性没有变化。结论：50毫克/天的异黄酮没有减少骨吸收，但猕猴桃和异黄酮消耗降低了血清ucoc水平，可能是由于维生素K1和/或绿色猕猴桃的其他生物活性成分。

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