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首页> 外文期刊>Artificial Organs >An appropriately sized soft polyester external stent prevents enlargement and neointimal hyperplasia of a saphenous vein graft in a canine model
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An appropriately sized soft polyester external stent prevents enlargement and neointimal hyperplasia of a saphenous vein graft in a canine model

机译：适当大小的柔软聚酯外支架可防止犬模型中的隐静脉移植物的放大和新内膜增生

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摘要

Abstract Although the efficacy of external stents for vein grafts in coronary artery bypass grafting has been recognized, the ideal diameter and material of the stent remain controversial. We created a new external stent made of soft polyester mesh and performed an animal experiment using canines. Bilateral saphenous vein grafts were interposed in the bilateral common carotid artery of 10 beagles. The grafts in the left carotid artery were designated as the control group, and those in the right rolled by a soft polyester mesh external stent were designated as mesh group. Two of the 10 animals were sacrificed due to severe wound infection. The other eight were observed by echography for 6 months, and then grafts were extracted and thickness of the neointima of the grafts was measured. The control group showed 146%?±?26% postoperative enlargement of the internal diameter of the vein grafts after 6 months, whereas the mesh group showed only 115%?±?15% after the same duration ( P ?=?0.0003). The median thickness of the neointima in the mesh group (170?μm [range: 150–190]) was significantly thinner than that in the control group (260?μm [range: 220–310], P ??0.0001). Some degree of correlation between the thickness of neointima and proportion of enlargement was noted ( r ?=?0.518, P ?=?0.0024). A soft polyester mesh external stent for vein grafts successfully suppressed the enlargement of the vein grafts and thickness of the neointima after 6 months.
机译：摘要虽然已经认识到冠状动脉旁路移植术中静脉移植物的外部支架的功效，但支架的理想直径和材料仍然存在争议。我们创建了一种由软涤纶网制成的新外支架，并使用犬进行动物实验。双侧隐静脉移植物插入在10兆头的双侧常见的颈动脉中。左颈动脉中的移植物被指定为对照组，并且由软涤纶网外支架轧制的右侧的那些被称为网状组。由于严重的伤口感染，使10只动物中的两个饲料。通过ECH术观察到其他八个月6个月，然后提取移植物，并测量移植物的内部厚度。对照组在6个月后显示静脉移植物的内径的146％？±26％，而网状基团在相同的持续时间后仅显示115％？±15％（p？= 0.0003）。网眼中的内部中午的中值厚度（170μm[范围：150-190]）显着薄于对照组（260Ωμm[范围：220-310]，p≤≤0.0001） 。注意到内部厚度与放大比例之间的一定程度的相关性（R？= 0.518，p？= 0.0024）。用于静脉移植物的软聚酯网外支架成功地抑制了6个月后静脉移植物和内部厚度的放大。

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