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首页> 外文期刊>Artificial Organs >In Vitro Study on the Dynamics of Blood Flow Impelled by an Alternating Current Magnetohydrodynamic Blood Pump
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In Vitro Study on the Dynamics of Blood Flow Impelled by an Alternating Current Magnetohydrodynamic Blood Pump

机译：通过交流式磁流动动力血液泵驾驶血流动力学的体外研究

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Abstract Artificial hearts are effective devices to treat heart failure in clinical practice and can be divided into two categories: artificial hearts and ventricular assist devices. The goal of this work was to investigate the fluidity and biological changes of in vitro sheep blood using a novel alternating current (AC) magnetohydrodynamic blood pump (central magnetic intensity: 0.9 T, alternating current frequency of the electric motor: 0–80 Hz). Blood samples were collected from five sheep and were divided into two groups: the control group (no exposure to an external magnetic field) and the exposed group (3 h of exposure to an alternating magnetic field). The blood cell counts, changes in blood viscosity, and ultrastructural changes of the blood cells under transmission electron microscopy were investigated. This study demonstrated several findings: (i) Continuous sheep blood flow can be achieved; (ii) The blood cell counts remained unchanged after 3 h of exposure to an alternating magnetic field; (iii) Compared with the control group, the high‐ and low‐shear viscosities of the whole blood from the sheep significantly decreased after 3 h of exposure to an alternating magnetic field ( P 0.05 and P 0.01, respectively). Plasma viscosity was significantly reduced after exposure to high‐intensity alternating magnetic fields ( P 0.001); (iv) The cytoplasm of blood cells (especially erythrocytes) became lighter in color in the exposure group compared to the control group, and “beads‐on‐string” aggregations of black particles appeared. This work provides detailed and reliable scientific research data for the development of this type of blood pump, which may serve as a transition to the clinical artificial heart.
机译：摘要人造心是治疗临床实践中心力衰竭的有效设备，可分为两类：人造心脏和心室辅助装置。这项工作的目标是使用新颖的交流（AC）磁性流动血泵（中央磁强：0.9T，电动机的交流频率：0-80Hz）来研究体外绵羊血液的流动性和生物学变化。从五只绵羊收集血液样品，分为两组：对照组（没有暴露于外部磁场）和暴露的基团（暴露于交替磁场3小时）。研究了血细胞计数，血液粘度的变化以及透射电子显微镜下血细胞的超微结构变化。本研究证明了几种结果：（i）可以实现连续羊血流; （ii）在接触交替磁场3小时后，血细胞计数保持不变; （iii）与对照组相比，在接触交流场（P <0.05和P <0.01分别）后，绵羊的全血的全血的高剪切粘度显着降低。暴露于高强度交流磁场后，血浆粘度显着降低（P <0.001）; （iv）与对照组相比，血液细胞（特别是红细胞）的细胞质（特别是红细胞）在暴露组中的颜色变得更轻，并出现了黑色颗粒的“珠子串”聚集。这项工作为这种类型的血液泵提供了详细且可靠的科学研究数据，这可能用作临床人造心脏的过渡。

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