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首页> 外文期刊>Artificial Organs >Autoregulation of coronary blood flow in the isolated beating pig heart
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Autoregulation of coronary blood flow in the isolated beating pig heart

机译：冠状动脉血流在孤立的殴打猪心脏上的自动调用

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摘要

The isolated beating pig heart model is an accessible platform to investigate the coronary circulation in its truly morphological and physiological state, whereas its use is beneficial from a time, cost, and ethical perspective. However, whether the coronary autoregulation is still intact is not known. Here, we study the autoregulation of coronary blood flow in the working isolated pig heart in response to brief occlusions of the coronary artery, to step-wise changes in left ventricular loading conditions and contractile states, and to pharmacologic vasodilating stimuli. Six slaughterhouse pig hearts (473±40g) were isolated, prepared, and connected to an external circulatory system. Through coronary reperfusion and controlled cardiac loading, physiological cardiac performance was achieved. After release of a coronary occlusion, coronary blood flow rose rapidly to an equal (maximum) level as the flow during control beats, independent of the duration of occlusion. Moreover, a linear relation was found between coronary blood flow and coronary driving pressure for a wide variation of preload, afterload, and contractility. In addition, intracoronary administration of papaverine did not yield a transient increase in blood flow indicating the presence of maximum coronary hyperemia. Together, this indicates that the coronary circulation in the isolated beating pig heart is in a permanent state of maximum hyperemia. This makes the model excellently suitable for testing and validating cardiovascular devices (i.e., heart valves, stent grafts, and ventricular assist devices) under well-controlled circumstances, whereas it decreases the necessity of sacrificing large mammalians for performing classical animal experiments.
机译：孤立的跳动猪心脏模型是一种可访问的平台，用于调查其真正的形态和生理状态的冠状动脉循环，而其使用是有益的，从时间，成本和道德的角度来看。然而，冠状动脉自动调节是否仍然完好无损。在这里，我们研究了冠状动脉短暂咬合的工作分离猪心脏中冠状动脉血流的自动调节，左心室负载条件和收缩状态的逐步变化，以及药理学血管舒张刺激。分离，制备六首屠宰场猪心（473±40g），并连接到外部循环系统。通过冠状动脉再灌注和受控心脏载荷，实现了生理心脏表现。在释放冠状动脉闭塞后，冠状动脉血流迅速升至相等的（最大）水平作为控制率期间的流动，与闭塞的持续时间无关。此外，在冠状动脉血流和冠状动脉驾驶压力之间发现了线性关系，用于预载荷，后载和收缩性的广泛变化。此外，罂粟碱的颅内施用并未产生血液流动的瞬态增加，表明存在最大冠状动脉充血。其中，这表明隔离的跳动猪心中的冠状动脉循环处于永久性的最大性高血症状态。这使得模型在良好控制的情况下使模型能够测试和验证心血管装置（即心脏瓣膜，支架移植物和心室辅助装置），而它会降低牺牲大型哺乳动物以进行古典动物实验的必要性。

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  • 来源
    《Artificial Organs》 |2013年第8期|共7页
  • 作者

    SchampaertS.; vantVeerM.; RuttenM.C.M.; vanTuijlS.; deHartJ.; vandeVosseF.N.; PijlsN.H.J.;

  • 作者单位

    Department of Biomedical Engineering Eindhoven University of Technology Eindhoven Netherlands;

    Department of Biomedical Engineering Eindhoven University of Technology Eindhoven Netherlands;

    Department of Biomedical Engineering Eindhoven University of Technology Eindhoven Netherlands;

    HemoLab Cardiovascular Engineering Eindhoven Netherlands;

    HemoLab Cardiovascular Engineering Eindhoven Netherlands;

    Department of Biomedical Engineering Eindhoven University of Technology Eindhoven Netherlands;

    Department of Biomedical Engineering Eindhoven University of Technology Eindhoven Netherlands;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 器官移植术;
  • 关键词

    Coronary autoregulation; Isolated beating heart; Maximum hyperemia; Porcine model;

    机译：冠状动脉自动调节;孤立的跳动心;最大的充血;猪模型;

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