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首页> 外文期刊>Artificial Organs >Effects of Nano-hydroxyapatite/Poly(DL-lactic-co-glycolic acid) Microsphere-Based Composite Scaffolds on Repair of Bone Defects: Evaluating the Role of Nano-hydroxyapatite Content
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Effects of Nano-hydroxyapatite/Poly(DL-lactic-co-glycolic acid) Microsphere-Based Composite Scaffolds on Repair of Bone Defects: Evaluating the Role of Nano-hydroxyapatite Content

机译：纳米羟基磷灰石/聚（D1-乳酸 - 共乙醇酸）微球基复合支架对骨缺损修复的影响：评价纳米羟基磷灰石含量的作用

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摘要

The aim of the current study was to prepare microsphere-based composite scaffolds made of nano-hydroxyapatite (nHA)/poly (DL-lactic-co-glycolic acid) (PLGA) at different ratios and evaluate the effects of nHA on the characteristics of scaffolds for tissue engineering application. First, microsphere-based composite scaffolds made of two ratios of nHA/PLGA (nHA/PLGA=20/80 and nHA/PLGA=50/50) were prepared. Then, the effects of nHA on the wettability, mechanical strength, and degradation of scaffolds were investigated. Second, the biocompatibility and osteoinductivity were evaluated and compared by co-culture of scaffolds with bone marrow stromal stem cells (BMSCs). The results showed that the adhesion, proliferation, and osteogenic differentiation of BMSCs with nHA/PLGA (50/50) were better than those with nHA/PLGA (20/80). Finally, we implanted the scaffolds into femur bone defects in a rabbit model, then the capacity of guiding bone regeneration as well as the in vivo degradation were observed by micro-CT and histological examinations. After 4 weeks' implantation, there was no significant difference on the repair of bone defects. However, after 8 and 12 weeks' implantation, the nHA/PLGA (20/80) exhibited better bone formation than nHA/PLGA (50/50). These results suggested that a proper concentration of nHA in the nHA/PLGA composite should be taken into account when the composite scaffolds were prepared, which plays an important role in the biocompatibility, degradation rate and osteoconductivity.
机译：目前研究的目的是在不同比例下制备由纳米羟基磷灰石（NHA）/聚（DL-乳酸 - 共乙醇酸）（PLGA）制备的微球基复合支架，并评估NHA对其特性的影响用于组织工程应用的脚手架。首先，制备由两种NHA / PLGA（NHA / PLGA = 20/80和NHA / PLGA = 50/50）制成的微球基复合支架。然后，研究了NHA对支架的润湿性，机械强度和降解的影响。其次，通过骨髓基质干细胞（BMSCs）的支架的共培养并进行评价生物相容性和骨诱导性。结果表明，NHA / PLGA（50/50）的BMSCs的粘附性，增殖和骨质发生分化优于NHA / PLGA（20/80）。最后，我们将支架植入兔模型中的股骨缺陷，然后通过微型CT和组织学检查观察引导骨再生以及体内降解的能力。 4周内植入后，骨缺损的修复没有显着差异。然而，在8和12周内植入后，NHA / PLGA（20/80）表现出比NHA / PLGA（50/50）更好的骨形成。这些结果表明，当制备复合支架时，应考虑NHA / PLGA复合材料中的适当浓度的NHA，这在生物相容性，降解速率和骨导电性中起重要作用。

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  • 来源
    《Artificial Organs》 |2016年第7期|共8页
  • 作者

    He Shu; Lin Kai-Feng; Sun Zhen; Song Yue; Zhao Yi-Nan; Wang Zheng; Bi Long; Liu Jian;

  • 作者单位

    Fourth Mil Med Univ Xijing Hosp Dept Orthopaed 127 West Changle Rd Xian 710032 Shaanxi;

    Fourth Mil Med Univ Xijing Hosp Dept Orthopaed 127 West Changle Rd Xian 710032 Shaanxi;

    Fourth Mil Med Univ Xijing Hosp Dept Orthopaed 127 West Changle Rd Xian 710032 Shaanxi;

    Fourth Mil Med Univ Xijing Hosp Dept Orthopaed 127 West Changle Rd Xian 710032 Shaanxi;

    Fourth Mil Med Univ Xijing Hosp Dept Orthopaed 127 West Changle Rd Xian 710032 Shaanxi;

    Fourth Mil Med Univ Xijing Hosp Dept Orthopaed 127 West Changle Rd Xian 710032 Shaanxi;

    Fourth Mil Med Univ Xijing Hosp Dept Orthopaed 127 West Changle Rd Xian 710032 Shaanxi;

    Fourth Mil Med Univ Xijing Hosp Dept Orthopaed 127 West Changle Rd Xian 710032 Shaanxi;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 器官移植术;
  • 关键词

    Nano-hydroxyapatite; Poly(DL-lactic-co-glycolic acid); Microsphere-based composite; Bone tissue engineering; Bone regeneration;

    机译：纳米羟基磷灰石;聚（DL-乳酸 - 共乙醇酸）;基于微球的复合材料;骨组织工程;骨再生;

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