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首页> 外文期刊>Artificial Organs >A Mock Circulatory System Incorporating a Compliant 3D-Printed Anatomical Model to Investigate Pulmonary Hemodynamics
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A Mock Circulatory System Incorporating a Compliant 3D-Printed Anatomical Model to Investigate Pulmonary Hemodynamics

机译：一种模拟循环系统，其包含符合标准的3D印刷解剖模型，用于研究肺血流动力学

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A realistic mock circulatory system (MCS) could be a valuable in vitro testbed to study human circulatory hemodynamics. The objective of this study was to design a MCS replicating the pulmonary arterial circulation, incorporating an anatomically representative arterial model suitable for testing clinically relevant scenarios. A second objective of the study was to ensure the system's compatibility with magnetic resonance imaging (MRI) for additional measurements. A latex pulmonary arterial model with two generations of bifurcations was manufactured starting from a 3D-printed mold reconstructed from patient data. The model was incorporated into a MCS for in vitro hydrodynamic measurements. The setup was tested under physiological pulsatile flow conditions and results were evaluated using wave intensity analysis (WIA) to investigate waves traveling in the arterial system. Increased pulmonary vascular resistance (IPVR) was simulated as an example of one pathological scenario. Flow split between right and left pulmonary artery was found to be realistic (54 and 46%, respectively). No substantial difference in pressure waveform was observed throughout the various generations of bifurcations. Based on WIA, three main waves were identified in the main pulmonary artery (MPA), that is, forward compression wave, backward compression wave, and forward expansion wave. For IPVR, a rise in mean pressure was recorded in the MPA, within the clinical range of pulmonary arterial hypertension. The feasibility of using the MCS in the MRI scanner was demonstrated with the MCS running 2 h consecutively while acquiring preliminary MRI data. This study shows the development and verification of a pulmonary MCS, including an anatomically correct, compliant latex phantom. The setup can be useful to explore a wide range of hemodynamic questions, including the development of patientand pathology-specific models, considering the ease and low cost of producing rapid prototyping molds, and the versatility of the setup for invasive and noninvasive (i.e., MRI) measurements.
机译：现实模拟循环系统（MCS）可以是体外试验台的有价值的，以研究人循环血流动力学。本研究的目的是设计一种复制肺动脉循环的MCS，其包含一种适用于测试临床相关场景的解剖学代表性动脉模型。该研究的第二个目的是确保系统与磁共振成像（MRI）的兼容性，以进行额外的测量。从从患者数据重建的3D印刷模具开始制造具有两代分叉的乳胶肺动脉模型。该模型被掺入MCS中，用于体外流体动力学测量。在生理脉冲流动条件下测试设置，并使用波强度分析（WIA）评估结果，以研究动脉系统中行进的波浪。模拟肺血管阻力增加（IPVR）作为一种病理情况的一个例子。发现右侧和左肺动脉之间的流动分别是现实的（分别为54和46％）。在整个各个分叉的各个等几代内部观察到压力波形中没有显着差异。基于WIA，在主要肺动脉（MPa）中鉴定出三个主波，即前向压缩波，向后压缩波和前向膨胀波。对于IPVR，在肺动脉高压的临床范围内，在MPA中记录平均压力的上升。使用MCS在初步MRI数据的同时连续运行2小时，使用MCS在MRI扫描仪中使用MCS的可行性。本研究表明，肺部MCS的开发和验证，包括解剖学上正确，柔顺的乳胶幻影。该设置可用于探索各种血液动力学问题，包括患者和病理学型号的开发，考虑到生产快速原型模具的缓和和低成本，以及用于侵入性和非侵入性的设置的多功能性（即MRI ） 测量。

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