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Preliminary Study of a Novel Puborectalis-Like Artificial Anal Sphincter

机译：一种新型猪凝视性人工肛门括约肌的初步研究

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摘要

Artificial anal sphincter (AAS) is an in situ implanted device that acts as a treatment for fecal incontinence regardless of etiology by augmenting the incompetent sphincteric structures. However, AAS is impeded from becoming a valid therapy by its high rate of ischemic complication and malfunction. This article presents an original puborectalis-like artificial anal sphincter (PAAS) that features a low risk of ischemia necrosis and rectal perception remodeling. The device retains continence by reproducing the action, including the pulling and angulating the rectum, of the puborectalis muscle, which forms the anorectal angle and reduces the required clamping pressure. Three rectal pressure sensors were embedded to maintain the pressure exerted on the rectal wall in a safe range and to monitor the distention of the rectum. A series of in vitro studies were conducted with a porcine rectum, and this PAAS prototype manifested the ability of maintaining continence with a clamping pressure considerably lower than that required by other AAS devices. The pressure sensors exhibit good linearity, and the function of rectal perception remodeling has also revealed high reliability with a success rate of 93.3%.
机译：人造肛门括约肌（AAS）是一种原位植入装置，其通过增强无能的括约的结构来充当粪便失禁的治疗方法。然而，通过其高缺血性并发症和故障来阻碍AAS成为有效的治疗。本文介绍了一种原始的普罗突型人工肛门括约肌（PAA），具有缺血坏死和直肠感知重塑的低风险。该装置通过再现葡萄球菌肌肉的动作来保留持续的动作，包括形成肛门直肠肌肉的抗腹肌，这形成肛门直角并降低所需的夹紧压力。嵌入三个直肠压力传感器以保持在安全范围内施加在直肠壁上的压力，并监测直肠的偏移。用猪直肠进行一系列体外研究，该PAA原型表现出维持欧洲堵塞的能力，其夹紧压力明显低于其他AAS装置所需的堵塞。压力传感器表现出良好的线性度，直肠感知重塑的功能也揭示了高可靠性，成功率为93.3％。

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