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首页> 外文期刊>Artificial Organs >Antiresorptive Agents are More Effective in Preventing Titanium Particle‐Induced Calvarial Osteolysis in Ovariectomized Mice Than Anabolic Agents in Short‐Term Administration
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Antiresorptive Agents are More Effective in Preventing Titanium Particle‐Induced Calvarial Osteolysis in Ovariectomized Mice Than Anabolic Agents in Short‐Term Administration

机译：在短期施用中预防卵巢切除小鼠的钛颗粒粒子诱导的颅粒骨质溶解而言，抗漏剂在短期施用中

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摘要

Abstract Aseptic loosening due to wear particle‐induced osteolysis is the main cause of arthroplasty failure and the influence of postmenopausal osteoporosis and anti‐osteoporosis treatment on Titanium (Ti) particle‐induced osteolysis remains unclear. 66 C57BL/6J female mice were used in this study. Ovariectomy (OVX) was performed to induce osteopenia mice and confirmed by micro‐CT. The Ti particle‐induced mouse calvaria osteolysis model was established subsequently and both OVX and Sham‐OVX mice were divided into four groups, respectively: Ti (‐) group, Ti group, Ti + zoledronic acid (ZOL) group (50ug/kg, local administration, single dose) and Ti + teriparatide (TPTD) group (40ug/kg/d, subcutaneous injection*14d). Mice calvarias were collected for micro‐CT and histomorphometric analysis 2 weeks after particle induction. 8 weeks after bilateral OVX, significantly reduced BMD and microstructure parameters in both proximal tibia and calvaria were observed in OVX mice when comparing with Sham‐OVX mice. OVX mice in Ti group had not only markly decreased BMD and BV/TV, but also significantly increased total porosity, eroded surface area and osteoclast numbers when comparing with Sham‐OVX mice. Shown by Two‐way ANOVA analysis, the interaction terms between OVX and Ti implantation on micro‐CT and histomorphometry parameters didn’t reach significant difference. As illustrated by micro‐CT and histological analysis, ZOL treatment markedly inhibited Ti particle‐induced osteolysis in OVX mice and Sham‐OVX mice, and there were significant differences when comparing to both Ti and Ti+TPTD group. The combination of osteoporosis and Ti particle implantation result in aggravated bone resorption, accompanied with increased osteoclasts and excessive inflammation response. ZOL was more effective in preventing Ti particle‐induced osteolysis in both OVX mice and Sham‐OVX mice than TPTD in short‐term administration. ZOL exert the protective effects on Ti particle‐induced bone loss via the suppression of osteoclasts.
机译：摘要由于磨损粒子诱导的骨溶解的无菌松动是关节成形术失败的主要原因，绝经后骨质疏松症和抗骨质疏松症治疗对钛（Ti）的抗骨质疏松症治疗的影响尚不清楚。在本研究中使用了66 C57BL / 6J雌性小鼠。进行卵巢切除术（OVX）以诱导骨膨胀症小鼠并通过微型CT证实。随后建立Ti粒子诱导的小鼠钙骨溶质解水模型，分别分为四组，Ti（ - ）组，Ti组，Ti +唑醇（ZOL）组（50ug / kg，局部给药，单剂量）和Ti + Teriparidide（TPTD）组（40ug / kg / d，皮下注射* 14d）。在颗粒诱导后2周为微型CT和组织素质分析收集小鼠Calvarias。在与假卵小鼠比较时，双侧ovx在双侧ovX后，在邻近胫骨和腹膜小鼠中显着降低了胫骨胫骨和卡瓦里亚的微观结构参数。 TI组的OVX小鼠不仅显着降低了BMD和BV / TV，而且在与假卵巢小鼠比较时，也显着增加了总孔隙率，侵蚀的表面积和骨质体积数。通过双向ANOVA分析表明，OVX和TI植入对微型CT和组织形态学参数之间的相互作用术语并没有达到显着差异。如微型CT和组织学分析所示，ZOL治疗显着抑制OVX小鼠和假卵小鼠的Ti颗粒诱导的骨解，并且与Ti和Ti + TPTD组相比，存在显着差异。骨质疏松症和Ti颗粒植入的组合导致加重的骨吸收，伴随着骨粒细胞增加和过量的炎症反应。在短期给药中，ZOL在预防TI颗粒诱导的TI颗粒诱导的骨质溶质和假胚小鼠中的溶血性比TPTD。 ZOL通过抑制破骨细胞施加对TI颗粒诱导的骨质损失的保护作用。

著录项

  • 来源
    《Artificial Organs》 |2018年第9期|共14页
  • 作者

    Fu Guangtao; Li Shixun; Ouyang Nengtai; Wu Junyan; Li Changchuan; Liu Wei; Qiu Junxiong; Peng Peng; Qin Ling; Ding Yue;

  • 作者单位

    Department of OrthopedicsSun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Yuexiu;

    Department of OrthopedicsSun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Yuexiu;

    Cellular &

    Molecular Diagnostics CenterSun Yat‐Sen Memorial Hospital Sun Yat‐Sen University;

    Department of PharmaceuticalsSun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Yuexiu;

    Department of OrthopedicsSun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Yuexiu;

    Department of OrthopedicsSun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Yuexiu;

    Department of OrthopedicsSun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Yuexiu;

    Department of OrthopedicsSun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Yuexiu;

    Musculoskeletal Research Laboratory Department of Orthopaedics &

    TraumatologyThe Chinese;

    Department of OrthopedicsSun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Yuexiu;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 器官移植术;
  • 关键词

    Ovariectomy; Wear particle; Osteolysis; Anabolics; Antiresorptives;

    机译：卵巢切除术;磨损粒子;骨溶解;合成代谢物;反射性;

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