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Mechanical properties of currently available left atrial appendage occlusion devices: A bench‐testing analysis

机译：目前可用的左心房附属封闭装置的机械性能：台阶测试分析

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Abstract Endoluminal left atrial appendage occlusion is an emerging therapy to treat patients suffering from atrial fibrillation with contraindications against oral anticoagulation. Different occlusion devices have been introduced into the clinical setting while comparative studies between the devices are sparse. This in vitro study compares several endoluminal left atrial appendage occlusion systems regarding 2 mechanical properties: radial (RF) and tug force (TF). Seven different occluder systems of various sizes (24 in total) underwent testing throughout their recommended sizing range. RF was measured in a commercial RF tester. TF was assessed according to a recently published bench test. RF increased with compression of the devices: The LAmbre 2228 device exerted the highest RF (8.6?N) at maximum compression of 16?mm. The lowest RF of 0.1?N was exhibited by the 27?mm Occlutech occluder at minimal compression. The highest TFs were exerted by the WaveCrest devices at maximum compression with 4.6 and 3.6?N for the 22?mm and the 27?mm device, respectively. The lowest TFs were measured for the first‐generation Occlutech devices, particularly for the 24?mm device with 1.1?N at maximum compression and 0.4?N at minimum compression. A strong positive correlation was found between the number of hooks per millimeter circumference of an occluder and its tug force ( r ?=?0.87, P ??0.01). The analysis revealed device stability to be more dependent on anchoring structures than on RF. The wide range of mechanical properties makes comparison of current LAA occluders difficult and emphasizes the need for standardized preclinical testing to prompt clinical compatibility.
机译：摘要内泌型左心房阑尾闭塞是一种新出现的治疗，治疗患有心房颤动的患者与禁忌症对口腔抗凝凝聚。已经将不同的遮挡装置引入临床环境中，而装置之间的比较研究是稀疏的。这种体外研究比较了关于2机械性能的几个内泌腔左心房阑尾闭塞系统：径向（RF）和拖轮力（TF）。七种不同的封闭系统各种尺寸（总共24个）在其推荐的尺寸范围内进行了经历过的测试。 RF在商业射频测试仪中测量。根据最近发表的替补测试评估了TF。 RF随着器件的压缩而增加：Lambre 2228器件在最大压缩中施加最高的RF（8.6ΩN）16Ωmm。在最小的压缩下，27毫米occlutech封堵器展出了0.1Ω的最低射频。波形仪器的最高TFS分别在最大压缩中施加最高的TFS，分别为22Ωmm和27Ωmm的最大压缩。测量最低TFS的第一代occlutech装置，特别是对于最大压缩以最大压缩，最大压缩的24毫米装置，最小压缩。在封堵器的每毫米圆周的钩子数和其拖轮力（R≥θ0.87，p≤0.87）之间发现了强烈的正相关性。该分析显示了装置稳定性更依赖于锚固结构而不是RF。各种机械性能使得当前LAA封闭仪的比较困难，并强调需要标准化的临床前测试以提示临床兼容性。

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