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首页> 外文期刊>Artificial Organs >Seroreversion of positive anti‐hepatitis C virus antibodies in left ventricular assist device recipients: Now you see them, now you don’t
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Seroreversion of positive anti‐hepatitis C virus antibodies in left ventricular assist device recipients: Now you see them, now you don’t

机译：左心室辅助装置接受者的阳性抗丙型肝炎病毒抗体的血液转化：现在你看到他们，现在你没有

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摘要

Abstract The clinical significance of positive anti‐hepatitis C virus (anti‐HCV) antibody tests in recipients of left ventricular assist devices remains unclear. In light of emerging evidence suggesting the possibility of persistent low‐level HCV infection in patients with positive anti‐HCV antibody test but negative HCV ribonucleic acid, it is very important to distinguish the truly false positive HCV antibodies, in recipients of continuous flow left ventricular assist devices, from those suggestive of a prior clinically resolved infection or one where a low‐level viremia may have persisted. We conducted a retrospective analysis of left ventricular assist device recipients at our institution. While the total incidence of positive HCV antibody with concomitantly negative HCV ribonucleic acid test (19.2%) was in keeping with the incidences reported in prior cross‐sectional studies, we longitudinally followed our patients and observed a 100% seroreversion. Seroreversion, which has not been reported in other studies, occurred either during continued left ventricular assist device support (10 out of 26) or after heart transplant (7 out of 26). Hundred percent seroreversion strongly suggested that the anti‐HCV antibodies were truly false positive.
机译：摘要阳性抗丙型肝炎病毒（抗HCV）抗体试验在左心室辅助装置受者中的临床意义尚不清楚。根据新兴的证据表明阳性抗HCV抗体试验患者持续低水平HCV感染的可能性，但阴性HCV核糖核酸的患者，区分真正的假阳性HCV抗体是非常重要的，在连续流动左心室的接受者中辅助设备，从那些暗示的临床分解感染或低水平毒蕈血症可能持续存在的那些。我们对我们机构的左心室辅助设备接受者进行了回顾性分析。虽然阳性HCV抗体的总发生率为伴随的阴性HCV核糖核糖核酸试验（19.2％）是在先前横截面研究中报告的发生率，但我们纵向跟随我们的患者并观察到100％的血红素。在其他研究中尚未报告的血红病发生在持续的左心室辅助装置支撑（26个中的10个）或心脏移植后（26分中的7）中发生。百分百的血红病强烈建议抗HCV抗体真正是假阳性的。

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