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首页> 外文期刊>Artificial Organs >Donkey pericardium compares favorably with commercial xenopericardia used in the manufacture of transcatheter heart valves
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Donkey pericardium compares favorably with commercial xenopericardia used in the manufacture of transcatheter heart valves

机译：驴心包与用于制造经转截管心阀的商业仇外比较有利

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Abstract Transcatheter aortic valve implantation (TAVI) has gained considerable acceptance in the past decade due to its lower risks than conventional open‐heart surgery. However, the deformation and delamination of the leaflets during the crimping procedure have raised questions about the durability and long‐term serviceability of the pericardium tissue from which the leaflets are made. The collagen architecture, wall thickness and mechanical properties of donkey pericardium were investigated to assess its suitability as an alternative material for the manufacture of heart valves. Coupons sampled from different locations of donkey pericardium were investigated. Bovine, equine, and porcine pericardium specimens served as controls. The donkey pericardium had a similar surface morphology to that of the control pericardia except for the wavy topology on both the fibrous and serous sides. The average thickness of donkey pericardium (ca. 120?μm) was significantly lower than that from bovine (375?μm) and equine (410?μm), but slightly higher than that from porcine (99?μm) specimens. The interlaced wavy collagen bundles in the pericardium were composed of collagen fibers about 100?nm in diameter. This unique structure ensures that the donkey pericardium has a comparable ultimate tensile strength (UTS) and a much higher failure strain than the commercial pericardia used for the manufacture of heart valves. The donkey pericardium has an organized wavy collagen bundle architecture similar to that of bovine pericardium and has a satisfactory UTS and high failure strain. The thin and strong donkey pericardium might be a good candidate valve leaflet material for TAVI.
机译：摘要因传统露天手术的风险较低，过去十年来，现经转导管主动脉瓣植入（Tavi）已经取得了相当大的验收。然而，在压接程序期间传单的变形和分层已经提出了关于牙细胞组织的耐久性和长期可用性的问题。研究了驴心包的胶原型架构，壁厚和机械性能，以评估其作为制造心脏瓣膜的替代材料的适用性。研究了从驴心包的不同地点采样的优惠券。牛，马和猪心包标本用作对照。除了纤维状和浆液侧面的波浪拓扑外，驴心包与对照心包的表面形态相似。驴心包（CA.120.≤μm）的平均厚度明显低于牛（375μm）和马（410Ωμm），但略高于猪（99Ωμm）标本。心包中的交织波状胶原束在直径约为100μm的胶原纤维组成。这种独特的结构可确保驴子膜具有可比的极限拉伸强度（UT）和比用于制造心脏瓣膜的商业包装物更高的失效菌株。驴心包有一个组织的波浪胶原束束架，类似于牛心包，具有令人满意的UTS和高失效应变。薄而强壮的驴心包可能是Tavi的良好候选阀门扇形材料。

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  • 来源
    《Artificial Organs》 |2019年第10期|共12页
  • 作者

    Mao Jifu; Rassoli Aisa; Tong Yiwei; Rouse Elizabeth Nicole; Le‐Bel Gaёtan; How Daniel; Germain Lucie; Fatouraee Nasser; Zhang Ze; Reed Robert R.; Guidoin Robert;

  • 作者单位

    Department of Surgery Faculty of MedicineUniversité LavalQuébec QC Canada;

    Department of Surgery Faculty of MedicineUniversité LavalQuébec QC Canada;

    Department of Surgery Faculty of MedicineUniversité LavalQuébec QC Canada;

    Department of Biomedical and Diagnostic SciencesCollege of Veterinary MedicineKnoxville Tennessee;

    Department of Surgery Faculty of MedicineUniversité LavalQuébec QC Canada;

    Addenbrooke's HospitalCambridge University Hospitals NHS Foundation TrustCambridge United Kingdom;

    Department of Surgery Faculty of MedicineUniversité LavalQuébec QC Canada;

    Biological Fluid Mechanics Research Laboratory Biomedical Engineering FacultyAmirkabir University;

    Department of Surgery Faculty of MedicineUniversité LavalQuébec QC Canada;

    Department of Biomedical and Diagnostic SciencesCollege of Veterinary MedicineKnoxville Tennessee;

    Department of Surgery Faculty of MedicineUniversité LavalQuébec QC Canada;

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  • 正文语种 eng
  • 中图分类 器官移植术;
  • 关键词

    collagen architecture; donkey pericardium; tissue thickness; transcatheter heart valve;

    机译：胶原蛋白建筑;驴心包;组织厚度;经导管心阀;

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