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首页> 外文期刊>Acta Psychiatrica Scandinavica >Three-year course of clinical symptomatology in young people at ultra high risk for transition to psychosis.
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Three-year course of clinical symptomatology in young people at ultra high risk for transition to psychosis.

机译：在过渡到精神病的极高风险中的年轻人，临床症状为期三年。

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OBJECTIVE: The investigation into the course of ultra high risk (UHR) symptomatology of those patients who eventually do not meet the psychosis-threshold criteria within the 3-year timeframe of the study. METHOD: The course of UHR symptoms, GAF score and employment status was investigated in 57 patients who did not make a transition to psychosis and who were examined within the Dutch Prediction of Psychosis Study in Amsterdam, the Netherlands. RESULTS: At the 3-year follow-up, 75% of the patients who did not make a transition to psychosis had remitted from UHR status. With a Generalized Estimation Equation Model it was shown that this group recovered from positive (F = 52.7, P < 0.0001), negative (F = 24.3, P < 0.0001), disorganization (F = 14.4, P < 0.0001) and general symptoms (F = 25.0, P < 0.0001) within the timeframe of the study. In addition, the level of global functioning and likelihood of having a job and/or education significantly improved. The largest improvements occurred within the first year. UHR symptoms did not re-occur after improvement. CONCLUSION: With the current UHR criteria, a large percentage of the included subjects appear to have transitory complaints and dysfunctioning. A refinement of the UHR criteria may diminish the chance of including 'false positives' in future UHR studies.
机译：目的：对在研究的三年时间内最终未达到精神病阈值标准的那些患者进行超高危（UHR）症状过程的调查。方法：对57名未转变为精神病的患者进行了UHR症状，GAF评分和就业状况的调查，这些患者在荷兰阿姆斯特丹的荷兰精神病预测研究中进行了检查。结果：在3年的随访中，未转变为精神病的患者中有75％已从UHR状态缓解。通过广义估计方程模型显示，该组患者从阳性（F = 52.7，P <0.0001），阴性（F = 24.3，P <0.0001），混乱（F = 14.4，P <0.0001）和一般症状中恢复在研究的时间范围内F = 25.0，P <0.0001）。此外，全球职能水平以及获得工作和/或受教育的可能性也得到了显着提高。最大的改进发生在第一年。改善后没有再次出现UHR症状。结论：根据目前的UHR标准，纳入的受试者中有很大一部分似乎具有短暂的不适和功能障碍。完善UHR标准可能会减少将来的UHR研究中包括“误报”的机会。

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