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首页> 外文期刊>Acta Psychiatrica Scandinavica >Incidence and lifetime risk of dementia and Alzheimer's disease in a Southern European population.
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Incidence and lifetime risk of dementia and Alzheimer's disease in a Southern European population.

机译：南欧人口中痴呆症和阿尔茨海默氏病的发病率和终生风险。

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OBJECTIVE: To calculate both the incidence rates and the lifetime risk (LTR) of dementia and Alzheimer's disease (AD). METHODS: A two-phase case-finding procedure was implemented in a cohort of 4057 cognitively intact individuals 55+ years of age living in Zaragoza, Spain, and followed-up at 2.5 and 4.5 years. Age- and sex-specific incidence rates were calculated. A mortality-adjusted, multivariate model was used to document LTRs. RESULTS: The incidence rate of dementia continued to rise after the age of 90 years, but was slightly lower than in North and West European studies. Only a tendency for an increased LTR with age was observed. Thus, LTR was 19.7% for a 65-year-old woman and 20.4% at the age of 85 years, the corresponding figures for AD being 16.7% and 17.6%. The LTR of AD was higher in women and was about twice as high among illiterate individuals when compared with individuals with higher educational levels. CONCLUSIONS: The incidence rate of dementia in this Southern European city was slightly lower than in previous studies in North-West Europe. LTR of dementia and AD seems to be slightly increased with age. The association of illiteracy with higher LTR of AD is intriguing.
机译：目的：计算痴呆症和阿尔茨海默氏病（AD）的发病率和终生风险（LTR）。方法：在西班牙萨拉戈萨的4057名55岁以上认知完好无损的人群中，实施了两阶段病例寻找程序，并分别随访2.5和4.5岁。计算了按年龄和性别分类的发病率。使用死亡率调整的多变量模型记录LTR。结果：90岁后痴呆症的发病率持续上升，但略低于北欧和西欧的研究。仅观察到随着年龄的增长LTR增加的趋势。因此，对于65岁的女性，LTR为19.7％，在85岁时为20.4％，相应的AD分别为16.7％和17.6％。与具有较高文化水平的人相比，女性的AD LTR较高，在文盲人群中，其LTR约为后者的两倍。结论：在这个欧洲南部城市中，痴呆症的发病率略低于以前在西北欧洲的研究。痴呆和AD的LTR似乎随着年龄的增长而略有增加。文盲与AD的较高LTR的关联很有趣。

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