The epigenetics of the hypothalamic-pituitary-adrenal axis in fetal development

Montenegro Yorran Hardman A.; Nascimento Denise de Queiroga; de Assis Thiago Oliveira; Dos Santos-Lopes Simone Silva

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The epigenetics of the hypothalamic-pituitary-adrenal axis in fetal development

机译：胎儿发育中下丘脑 - 垂体 - 肾上腺轴的表观学

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The hypothalamic-pituitary-adrenal (HPA) axis is an important hormonal mechanism of the human body and is extremely programmable during embryonic and fetal development. Analyzing its development in this period is the key to understanding in fact how vulnerabilities of congenital diseases occur and any other changes in the phenotypic and histophysiological aspects of the fetus. The environment in which the mother is exposed during the gestational period can influence this axis. Knowing this, our objective was to analyze in recent research the possible impact of epigenetic programming on the HPA axis and its consequences for fetal development. This review brought together articles from two databases: ScienceDirect and PUBMED researched based on key words such as "epigenetics, HPA axis, cardiovascular disease, and circulatory problems" where it demonstrated full relevance in experimental and scientific settings. A total of 101 articles were selected following the criteria established by the researchers. Thus, it was possible to verify that the development of the HPA axis is directly related to changes that occur in the cardiovascular system, to the cerebral growth and other systems depending on the influence that it receives in the period of fetal formation.

机译：下丘脑 - 垂体 - 肾上腺（HPA）轴是人体的重要激素机制，在胚胎和胎儿发育过程中是极其可编程的。在此期间分析其发展是理解的关键，实际上如何发生先天性疾病的脆弱性以及胎儿的表型和组织生物学方面的任何其他变化。母亲在妊娠期期间暴露的环境可以影响该轴。了解这一点，我们的目标是在近期研究表观遗传规划对HPA轴的可能影响及其对胎儿发育的影响。该审查将文章从两个数据库中汇集在一起：基于关键词，如“表观生物，HPA轴，心血管疾病和循环问题”等关键词，在诸如“表观生物学，HPA轴，心血管疾病和循环问题”中，展示了在实验和科学环境中的完全相关性。在研究人员建立的标准之后，共选了101篇文章。因此，可以验证HPA轴的发育与心血管系统中发生的变化直接相关，脑生长和其他系统取决于其在胎儿期间接受的影响。

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来源
《Annals of Human Genetics》 |2019年第4期|共19页
作者
Montenegro Yorran Hardman A.; Nascimento Denise de Queiroga; de Assis Thiago Oliveira; Dos Santos-Lopes Simone Silva;
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作者单位

Univ Estadual Paraiba Lab Genet &

Biol Mol Campus 1 Campina Grande Brazil;

Univ Fed Pernambuco UFPE LIKA Recife PE Brazil;

Univ Fed Paraiba Joao Pessoa Paraiba Brazil;

Univ Estadual Paraiba Lab Genet &

Biol Mol Campus 1 Campina Grande Brazil;

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原文格式 PDF
正文语种 eng
中图分类医学遗传学;
关键词
epigenetic; gestational period; hormonal mechanism; HPA;

机译：表观遗传;妊娠期;荷尔蒙机制;HPA;

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专利

1. The epigenetics of the hypothalamic-pituitary-adrenal axis in fetal development [J] . Montenegro Yorran Hardman A., Nascimento Denise de Queiroga, de Assis Thiago Oliveira, Annals of Human Genetics . 2019,第Pta4期

机译：胎儿发育中下丘脑 - 垂体 - 肾上腺轴的表观学
2. Central regulation of the hypothalamic-pituitary-adrenal axis during fetal development in the Guinea-pig. [J] . Owen D, Banjanin S, Gidrewicz D, Journal of neuroendocrinology . 2005,第4期

机译：豚鼠胎儿发育过程中下丘脑-垂体-肾上腺轴的中央调节。
3. Cardiovascular and hypothalamic-pituitary-adrenal axis development in late gestation fetal sheep and young lambs following modest maternal nutrient restriction in early gestation [J] . P. Hawkins, C. Steyn, H. H. G. McGarrigle Reproduction, fertility, and development . 2000,第7a8期

机译：妊娠后期适度限制母体营养后，妊娠晚期胎儿绵羊和幼羊的心血管和下丘脑-垂体-肾上腺轴发育
4. Non-Imprinted Epigenetics in Fetal and Postnatal Development and Growth [C] . Keith M. Godfrey, Karen A. Lillycrop, Graham C. Burdge, Nestlé Nutrition Workshop . 2013

机译：胎儿和产后开发和生长中的非印记表观生态学
5. Estrogen regulation of the pregnant baboon placental 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-catalyzed metabolism of cortisol and cortisone and its effect on the development of the fetal hypothalamic-pituitary-adrenal axis. [D] . Davies, William Adair. 2001

机译：孕妇狒狒胎盘11β-羟类固醇脱氢酶（11β-HSD）催化的皮质醇和可的松的代谢及其对胎儿下丘脑-垂体-肾上腺轴发育的影响。
6. The Hypothalamic-Pituitary-Adrenal Axis: Development Programming Actions of Hormones and Maternal-Fetal Interactions [O] . Julietta A. Sheng, Natalie J. Bales, Sage A. Myers, 2020

机译：下丘脑 - 垂体 - 肾上腺轴：发育激素的编程作用以及母体胎儿相互作用
7. Effect of maternal nutrient restriction in early gestation on development of the hypothalamic-pituitary-adrenal axis in fetal sheep at 0.8-0.9 of gestation [O] . P Hawkins, C Steyn, HH McGarrigle, 1999

机译：母体养分限制在妊娠0.8-0.9的胎儿绵羊丘脑 - 垂体肾上腺轴上发展的早期妊娠

The epigenetics of the hypothalamic-pituitary-adrenal axis in fetal development

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