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首页> 外文期刊>Annals of Human Genetics >Apolipoprotein E Polymorphism and Left Ventricular Failure in Beta-Thalassemia: A Multivariate Meta-Analysis
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Apolipoprotein E Polymorphism and Left Ventricular Failure in Beta-Thalassemia: A Multivariate Meta-Analysis

机译：载脂蛋白E多态性和β-地中海贫血的左心室失效：多变量荟萃分析

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摘要

Apolipoprotein E (ApoE) is potentially a genetic risk factor for the development of left ventricular failure (LVF), the main cause of death in beta-thalassemia homozygotes. In the present study, we synthesize the results of independent studies examining the effect of ApoE on LVF development in thalassemic patients through a meta-analytic approach. However, all studies report more than one outcome, as patients are classified into three groups according to the severity of the symptoms and the genetic polymorphism. Thus, a multivariate meta-analytic method that addresses simultaneously multiple exposures and multiple comparison groups was developed. Four individual studies were included in the meta-analysis involving 613 beta-thalassemic patients and 664 controls. The proposed method that takes into account the correlation of log odds ratios (log(ORs)), revealed a statistically significant overall association (P-value = 0.009), mainly attributed to the contrast of E4 versus E3 allele for patients with evidence (OR: 2.32, 95% CI: 1.19, 4.53) or patients with clinical and echocardiographic findings (OR: 3.34, 95% CI: 1.78, 6.26) of LVF. This study suggests that E4 is a genetic risk factor for LVF in beta-thalassemia major. The presented multivariate approach can be applied in several fields of research.
机译：载脂蛋白E（Apoe）可能是左心室失败（LVF）的发展的遗传危险因素，β-地中海贫血纯粹死亡的主要原因。在本研究中，我们通过META分析方法综合研究APOE对脑血病患者LVF发育的影响的独立研究结果。然而，所有研究报告了多于一个结果，因为根据症状和遗传多态性的严重程度，患者分为三组。因此，开发了一种多变量的元分析方法，其同时解决多种曝光和多个比较组。在涉及613β-Thalassimic患者和664例对照的荟萃分析中包含四项个体研究。考虑Log Datios比率的相关性的所提出的方法（Log（OR））揭示了统计学上显着的整体关联（p值= 0.009），主要归因于e4对患者的E4对E3等位基因的对比度（或：2.32,95％CI：1.19,4.53）或临床和超声心动图的患者（或：3.34,95％CI：1.78,6.26）的LVF。本研究表明，E4是β-地中海贫血血症中LVF的遗传危险因素。呈现的多变量方法可以应用于几个研究领域。

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