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首页> 外文期刊>Annals of Human Genetics >Changes of the echocardiographic parameters in chronic heart failure patients with Ile337val, Glu23lys, and Ser1369ala polymorphisms of genes encoding the ATP‐sensitive potassium channels subunits in the Ukrainian population
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Changes of the echocardiographic parameters in chronic heart failure patients with Ile337val, Glu23lys, and Ser1369ala polymorphisms of genes encoding the ATP‐sensitive potassium channels subunits in the Ukrainian population

机译：ILE337VAL，GLU23LY和SER1369ALA多态性慢性心力衰竭患者的超声心动造影参数的变化，乌克兰人群中的ATP敏感钾通道亚基的基因

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摘要

Abstract Different allelic variants of genes that encode ATP‐sensitive potassium (K ATP ) channels’ subunits may contribute to the development of heart failure. The purpose of the work to investigate SNPs in genes that encode K ATP channels in relation to echocardiographic parameters in chronic heart failure (CHF) patients. Ninety‐nine people with CHF of ischemic origin with left ventricular systolic dysfunction were examined. The control group is represented by 108 clinically healthy subjects. KCNJ11 polymorphisms Ile337Val and Glu23Lys, and ABCC8 polymorphism Ser1369Ala were genotyped using polymerase chain reaction. In CHF patients, the frequency of the Ile337Val genotype was: Ile/Ile, 40.4%; Ile/Val, 45.5%; and Val/Val, 14.1%. The patients with the Val/Val genotype had left ventricular (LV) mass that was 334.15?g, which was 27.3% ( P? ?0.05) lower versus Ile/Val patients (425.48?g). The index of this parameter was also significantly lower (28.4%, P? ?0.05). In CHF patients, the frequency of Glu23Lys and Ser1369Ala was: Glu/Glu and Ser/Ser, 43.4%; heterozygote, 44.4%; Lys/Lys and Ala/Ala, 12.2%. The patients with the Lys/Lys and Ala/Ala genotypes had a significantly lower LV mass index and LV end‐diastolic volume (22.9% and 26.8%, P? ?0.05) versus heterozygotes. Thus, the greatest LV mass and LV end‐diastolic volume values are associated with heterozygotes, while the smallest are associated with minor homozygotes.
机译：摘要编码ATP敏感钾（K ATP）通道亚基的不同基因的不同等位基因变体可能有助于开发心力衰竭。研究在基因中调查SNP的作品的目的，该基因编码K ATP通道的基因术中慢性心力衰竭（CHF）患者的超声心动图参数。检查患有左心室收缩功能障碍缺血性功能障碍的九十九人。对照组由108个临床健康受试者表示。 KCNJ11多态性ILE337VAL和GLU23LYS，ABCC8多态性SER1369ALA使用聚合酶链反应进行基因分型。在CHF患者中，ILE337VAL基因型的频率为：ILE / ILE，40.4％; ILE / VAL，45.5％;和val / val，14.1％。 val / val基因型的患者具有334.15μm的左心室（LV）质量，其为27.3％（p≤≤0.05），患有ILE / VAL患者（425.48μl）。该参数的指数也显着降低（28.4％，p≤0.05）。在CHF患者中，GLU23LYS和SER1369ALA的频率是：GLU / GLU和SER / SER，43.4％;杂合子，44.4％; Lys / Lys和Ala / Ala，12.2％。 Lys / Lys和ALA / ALA基因型的患者具有显着降低的LV质量指数和LV端舒张抑制体积（22.9％和26.8％，p≤≤0.05）与杂合子。因此，最大的LV质量和LV端舒张抑制体积值与杂合子相关，而最小的含有次要纯合子有关。

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  • 来源
    《Annals of Human Genetics》 |2018年第5期|共8页
  • 作者

    Strutynskyi R. B.; Voronkov L. G.; Nagibin V. S.; Mazur I. D.; Stroy D.; Dosenko V. E.;

  • 作者单位

    Department of General and Molecular Pathophysiology Bogomoletz Institute of PhysiologyNational;

    Department of Heart FailureState Institution ?National scientific center ?M.D. Strazhesko Institute;

    Department of General and Molecular Pathophysiology Bogomoletz Institute of PhysiologyNational;

    Department of Heart FailureState Institution ?National scientific center ?M.D. Strazhesko Institute;

    Department of General and Molecular Pathophysiology Bogomoletz Institute of PhysiologyNational;

    Department of General and Molecular Pathophysiology Bogomoletz Institute of PhysiologyNational;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学遗传学;
  • 关键词

    Chronic heart failure; echocardiography; rs5215; rs5219; rs757110;

    机译：慢性心力衰竭;超声心动图;RS5215;RS5219;RS757110;

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