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首页> 外文期刊>BJOG: an international journal of obstetrics and gynaecology >Prescriptions filled during pregnancy for drugs with the potential of fetal harm.
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Prescriptions filled during pregnancy for drugs with the potential of fetal harm.

机译：怀孕期间开出的处方可能会危害胎儿。

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OBJECTIVE: To assess the extent of prescriptions filled by pregnant women for drugs with recognised potential of fetal harm, and to document the outcomes of these pregnancies. DESIGN: Cross-sectional study. POPULATION: Quebec Pregnancy Registry. METHODS: We identified women who were pregnant during a five-year period and who were insured for prescription medications under the provincial drug plan. We obtained information on prescriptions filled during pregnancy for drugs with known potential of fetal harm. MAIN OUTCOME MEASURES: Prescriptions filled for study drugs during the first, second and third trimesters of pregnancy; termination of pregnancy (TOP) or delivery, and whether the baby was diagnosed with a major congenital malformation (MCM). RESULTS: Of 109 344 women, 56% filled at least one prescription for a medication during pregnancy; 6.3% filled at least one prescription for a drug known to pose a risk to the fetus. Overall, 47% (95% CI, 45.8-48.2) of pregnancies exposed to drugs under study ended in TOP versus 36.2% (95% CI, 35.9-36.5) of those not exposed; 8.2% (95% CI, 8.0-10.0) of live births were diagnosed with an MCM during the first year of life versus 7.1% (95% CI, 6.9-7.3) of those not exposed. CONCLUSIONS: This study documents an important level of prescriptions filled during pregnancy for drugs harmful to the developing fetus. The proportions of both TOPs and babies born with MCMs were elevated compared with the expected values. Clinicians caring for women during pregnancy should conduct a medication inventory prior to a planned pregnancy, or as soon as an unplanned pregnancy is recognised.
机译：目的：评估孕妇对具有公认的可能危害胎儿的药物开出的处方的范围，并记录这些怀孕的结果。设计：横断面研究。人口：魁北克怀孕登记处。方法：我们确定了在五年内怀孕并根据省级药物计划为处方药投保的妇女。我们获得了在怀孕期间为已知可能危害胎儿的药物开具的处方信息。主要观察指标：在怀孕的第一，第二和第三三个孕期填充研究药物的处方;终止妊娠（TOP）或分娩，以及婴儿是否被诊断出患有严重的先天性畸形（MCM）。结果：在109 344名妇女中，有56％的人在怀孕期间至少填写了一张药物处方; 6.3％的人对已知会对胎儿构成危险的药物至少开出了一张处方。总体而言，接受研究药物暴露的孕妇中有47％（95％CI，45.8-48.2）的孕妇以TOP结尾，而未暴露药物中的36.2％（95％CI，35.9-36.5）。在生命的第一年中，有8.2％（95％CI，8.0-10.0）的活产儿被诊断出患有MCM，而没有暴露的婴儿中有7.1％（95％CI，6.9-7.3）。结论：这项研究记录了怀孕期间对胎儿发育有害药物的重要处方水平。与预期值相比，TOP和MCM婴儿的比例均升高。怀孕期间照顾妇女的临床医生应在计划怀孕之前或一旦识别出计划外怀孕后进行药物清单。

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